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Welcome to the LEAP Technologies wiki, a digital brochure and literature catalog library of LEAP's PAL applications mainly based on the PAL x,y,z robot. For our Standard Product offering please visit thePALCenter For GSA please visit the following LEAP GSA GS-07F-0186U

 ↳ leaptec.com
 ↳ leapwiki.com

Company Description

LEAP Technologies, Inc. was founded in 1989 as an autosampler company serving the GC and GC–MS markets. Since then, LEAP has expanded into front-end sample handling for all areas of chromatography and mass spectroscopy, including LC/MS/MS and MALDI-MS as well as robotics for proteomics and fiber optic UV technology for tablet dissolution. LEAP strives to find total solutions for analytical lab automation. One of the major components in LEAP's approach to automation solutions is with the PAL X,Y,Z robot.LEAP Technologies All Things PAL™ Simplify with One Call, One Source, One Purchase Order! Buy direct from LEAP & enjoy our undivided attention, product expertise, and more.
Visit our newly opened and constantly expanding “PAL SupportCenter” to see our newest standard offerings of Instruments, Customizations, Service and Consumables

The LEAP Story

LEAP is experienced in providing automation solutions for any process that gathers, treats and delivers samples to an analytical process. Liquid Handling is in most cases involved but we are not limited to that. We can also move,weigh and image objects. Liquid handling includes spraying and printing besides the usual measuring, pipetting, injecting, mixing , heating or sampling of a variety of liquids. We have the ability to design, engineer, deliver and support simple but unique or complex but simple to use systems. The LEAP Shell software lets us create solution-specific sample lists and shell methods that synchronize all instruments involved. LEAP Shell is used for LC/LCMS and stand-alone workstations. LEAP uses Chronos Mastersoftwarefor GC and GC-MS integrations. Currently, Chronos integrates with Thermo Electron Xcalibur 1.4 and 2.0 GC & Agilent GC and MSD ChemStation. Further data system packages are begin integrated with Chronos so check with LEAP to see if yours is.
We can provide complete locked-down systems to Value Added Resellers (VARs). Combinations of instruments that we can supply are robotic sampling devices and LC pumps as front-end to LC-MS systems. Single and dual channel LC to one MS that save cycle time and therefore increase throughput are becoming standard Frontend Automation Bundles (FABs). LEAP has available a proven SDK for PAL integration into your data system software.
One of LEAP's fundamental business philosophies is to build strong client relationships by knowing our customers and responding to their specific needs with superior personal service whether you have one PAL or are VAR of LEAP's.

Chief Chromatographic Techniques Supported:

• LC-Fraction Collection for purification(semi-prep)
• LC–MS Sample Handlers providing sample just before injection
• GC and GC–MS Sample Prep such as Headspace,SPME, 96-well Filtration, ITSP,MEPS, Derivatization, SPEwith different injection techniques
• LC pumps for 50nl-2ml flow rates applicable to standard, micro and capillary columns
• 2D LC systems with sample handlers PAL for nano spray, nano fractionation to MALDI and other fraction collection schemes

A Sampling of Markets Served:

• Pharma / Biotech
• Polymer / Chemical
• Proteomics
• Forensic
• Food and Beverage
• Fragrance
• Environmental
• Fuel

Application Solutions

Application Solutions

LEAP strives to find standardized solutions creating the total package for all industries using analytical processes for small and large molecules in extracted liquids, solids, and in human, animal and plant tissues. We provide the precise robotics and efficient sample prep required by modern measurement techniques such as mass spectroscopy. For more details, contact the LEAP office.

• Analyzing a Plant Extract

• Balance PAL

• Biofuel Applications

• Direct Analysis in Real Time (DART®)

• GC Headspace

• Filtering of Samples

• Hydrogen Deuterium Exchange

• LC Multi-Valve Applications

• MALDI Applications

• NMR Sample Prep

• Polymer Analysis

• Process Monitoring Applications

• Purification Applications

• Radiolabeling

• Refractometer

• Semi Solid Applications

• Small Volume Fraction Collection - Collect PAL

• Solid Phase Extraction

• SPME

• Tobacco Analysis

LEAP Integrated Components

Accessories
PAL Accessories and Options - a concept you can grow with for your CTC Analytics Autosampler. For more details, contact the LEAP office.

• Bar Code Reading

• Column Heating

• Cooling and Heating Sample Storage

• Filtering of Samples

• Headspace

• Large Volume Dispensing

• Mixing of Samples

• Unique Storage

• Unique Injections

• Valve Washing

• XChange

Examples of Special Solutions

Example Solutions

Examples of some customized applications we have provided. We call them "LEAP Specials". They are custom made to suit your exact needs. Let us show you how automation can make your life in the laboratory easier, more efficient, and more rewarding. Turn Your CTC Autosampler into a LEAP WorkStation. The CTC PAL is a great autosampler but LEAP can improve upon it with one or more of our automated solutions. You dont have to know how - you just have to know LEAP. LEAP is experienced in providing automation solutions for any process that gathers, treats and delivers samples to an analytical process. Liquid Handling is in most cases involved but we are not limited to that. We can also move, weigh and image objects. Liquid handling includes spraying and printing besides the usual measuring, pipetting, injecting, mixing, heating or sampling of a variety of liquids. We have the ability to design, engineer, deliver and support simple but unique or complex but simple to use systems. We have various software packages to choose from including all major data systems. Our own LEAP Shell scheduling software let’s us create solution specific sample lists and Shell methods that synchronizes all instruments involved. We also can use Chronos Mastersoftware, Cycle Composer software, Cycle Editor and ICC-CE depending on your needs.
For more details, contact the LEAP office and provide the project code.

• Analysis of Total Iodine

• A Flexible LCMS Front End for High-Throughput Bioanalytical Analysis in GLP Environment

• Automated online liquid chromatographic/mass spectrometric metabolic study for prodrug stability

• Detecting a Carcinogen in Alcohol Beverages

• Dilute and incubate sample prior to LC injection

• Dual Channel Sample Cleanup

• EPA Method 8272

• Forced Degradation

• Forced Degradation - Dual PAL under LEAP Shell

• High SPEed for CTC PAL On-line Multidimensional SPE-SPE-LC of Raw Biofluids

• High Throughput Sample Analysis using Multiple Column LC/MS/MS and Automated Method Optimization Techniques

• Intrinsic Viscosity testing

• Increasing throughput of parallel on-line extraction liquid chromatography/electrospray ionization tandem mass spectrometry system for GLP quantitative bioanalysis in drug development

• Integrated high capacity solid phase extraction-MS/MS system for pharmaceutical profiling in drug discovery

• Kinetic Reaction with GC Injection

• Measuring nicotine partitioning from a tobacco smoke filter pad in an ammonia environment

• Multiplexing LC injections

• Multi-Valve system for selectable loop size

• One Step Derivitization

• Online Sample Cleanup using column switching with Multi-Valve system

• On-line SPE LC/MS/MS to Detect Organonitrogen and Triazine Pesticides in Drinking Water

• Pooling of vial contents for QC testing

• Productivity Package

• Rapid Precision Dispensing

• Sample Filtration with LEAP X-Press

• Sandwich Technique for Small Sample Volumes

• Sharper peaks using 2-stage low sample dispersal injection technique

• Simultaneous Screen of 23 Drugs of Abuse by LC API MS MS

• Single Drop Micro Extraction

• Static Headspace Gas Chromatography – Mass Spectrometry(SHS-GC–MS) Method for Monitoring the Formation of ethyl methane sulfonate from ethanol and methane sulfonic acid

• Tobacco Filtration - 96 Well Plate Filtration

• Tobacco Filtration - Large Volume Flask

• Twin PAL - High Throughput injections using Cycle Composer

• Using the PAL Autosampler as a Syringe Pump for MS Tuning

Search LEAP Wiki

Search LEAP Wiki

Glossary

Glossary

Videos

LEAP's PAL Application Videos on YouTube

LEAP Standard PAL offerings

Please click on our link below to go to the home page for the LEAP PAL products

thePALCenter LEAP Technologies

Consumables and Small Parts

LEAP consumables

 ↳ leaptec.com
 ↳ leapwiki.com

LEAP Technologies provides fully automated sample processing workstation instrumentation solutions based on the LEAP CTC PAL X, Y, Z syringe only autosampler robot. This extremely flexible, precise, and adaptable liquid handling robotic platform is available in a variety of lengths and options depending on the requirements of your sample preparation and injections for your UHPLC, LC or GC chromatography. LEAP also offers process control systems and stand alone workstations. LEAP is an open, neutral resource for technical support of existing PAL. Keep your PAL autosampler in peak working order LEAP offers full support and service for the PAL platform with over 11 years of history with the PAL. LEAP can also write custom macros, cycles, and scheduling software for your specific applications. We're proud that LEAP is known as a productivity improver for laboratories including government labs in agencies such as FDA, USDA, EPA, FBI, Armed Forces, Homeland Security and others function more efficiently. Robotic sample prep equipment works well in government labs and challenges lab technicians to keep feeding those more samples. Analytical equipment such as chromatographs and mass spectrometers are expensive devices and also expensive to maintain. LEAP can help to keep them running and analyze samples around the clock. LEAP has most of its laboratory automation robots under GSAcontract and is eager to service and maintain everything it sells to keep your expensive lab equipment running around the clock. CTC Analytics Combi PAL and HTS PAL for Front-End Automation for LC and GC applications. LEAP offers customized on-site training. LEAP Is continuing to develop FAQ, Solutions, Tips & Techniques,a Learning Center with the LEAP Wiki for the benefit of all PAL Platform Robotic users. We will continue exceeding customer expectations for quality, cost effective and efficient results using the most current technology and expertise in our industry. Our aim is to be the ultimate knowledge base on everything related to the PAL. LEAP is known as the autosamplerguys being in business over twenty years. LEAP has extensive multi-vendor experience with integrating the PAL. HTX, HTS, HTC, HTX-xt, HTS-xt, HTC-xt, LC-Mini, Combi PAL,COMBI-xt PAL, and GC PAL models. We have the Quality, Training, Parts availability, Infrastructure, and Experience.LEAP is sometimes referred to as an Application Automation House who is continually adding new products and solutions to its Lab Automation line. As we do so we change the content of this web site so please check back.
Please contact LEAP Technologies on how we can help you get maximized throughput with flexible pipetting automation solutions whether it is our standard applications or customized to your needs. The Combi-xt PAL autosampler is able to perform liquid and headspace analysis. Headspace options include Solid Phase Micro-extraction (SPME) and ITEX-2 as alternative to purge and trap. The HTS-xt PAL autosampler dramatically increases sample throughput by offering automated sample prep, Peltier cooled and heated sample storage using the cooled stack, Peltier cooled and heated sample storage using the cooled stack and low carryover due to the self-cleaning DLW (Dynamic Load and Wash) module and L-Mark syringes, peltier cooled valves and columns. LEAP provides automation that fits your needs and reduces errors, increases sample capacity, increases efficiency, reduces cost by supplying long term productivity improvements with user friendly software and flexible hardware. LEAP performs just in time or on time sample prep and inject. LEAP offers full support of integrated and non-integrated PAL software with both sales and support for Cruise Control, Cycle Composer and Cycle Composer Macro Editor, Agilent ChemStation CTC Control, Mass Hunter and EZChrom CTC integration, Xcalibur, Waters Masslynx or Analyst CTC Control software, Thermo (Finnegan) XCalibur, LEAP Shell, and Chronos software. LEAP has many new offerings including PAL XCHANGE Option for PAL-xt Systems with park station,plunger coupling,active needle guide, XCHANGE syringes at www.palxchange.com The PAL is more than just an autosampler, it is a high-quality and efficient laboratory robot platform that can be customized by LEAP Technologies to meet your specific needs. The LEAP Wiki is a knowledge base of PALWiki of some applications for the LEAP CTC PAL.

The PAL 3 is the latest offering from CTC Analytics for all of your GC or sample prep needs

Contact LEAP

Contact LEAP For additional information about LEAP and the PAL Platform, please contact LEAP Technologies.

The information and references contained in this web site are believed to be accurate and the most current information available.