Sandwich Technique for Small Sample Volumes


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Allows sandwiching of sample between user-selected volumes of wash solvent. In addition, after a user-specified delay, the injection valve is toggled back to the Load position and washed using the same solvent. This will be done after the standard syringe and valve wash sequence.

The pump system can get an injected signal that allows its program to increase flow rate for specific period of time to permit rapid introduction of sandwiched sample onto the column.


To control small sample volumes for capillary injections. Can help minimize sample carryover since the last solvent that the valve sees is wash solvent

Project Ref: H1066

For other cost/time saving measures consider:

  • LEAP offers multiple choices of Valve Self Wash Stations to aid in cleaning the valve [1]
  • Dual Channel Serial Injection with Front Cut (M-002) using Analyst and ICC-CE [2]
  • Dual Channel Parallel Injection (M-003) using Cycle Composer Software and Analyst [3]
  • “Look Ahead”, sample prep before injection (M-004) using LEAP Shell Software [4]
  • Dual Channel Parallel Injection (M-005) using LEAP Shell software [5]
  • Summary of LC Multi Valve Applications [6]
  • LEAP Shell Software and application for custom injections and scheduling [7]

Videos of PAL

LEAP's PAL Application Videos on YouTube

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LEAP strives to find total solutions for analytical lab automation by automating analytical processes for small and large molecules in extracted liquids, solids, and recently in human, animal and plant tissues. We provide the precise robotics and efficient sample prep required by modern measurement techniques such as MALDITOF mass spectroscopy. Our newest specialty customization of CTC Analytics’ PAL features small workstations that can perform complex liquid handling tasks including HPLC-Purification, SPE, filtration, weighing, heating and stirring. They can be configured as stand alone units or integrated for “just in time” sample prep for LC-MS or GC-MS analysis.
LEAP provides automated workstation instrumentation solutions based on the LEAP CTC PAL X, Y, Z syringe only autosampler robot from LEAP Technologies. This extremely flexible, precise, and adaptable liquid handling robotic platform is available in a variety of lengths and options depending on the requirements of your sample preparation and injections for your UHPLC, LC or GC chromatography.LEAP offers full support and service for the PAL platform in addition to being able to write custom macros, cycles, and scheduling to your applications. Please contact LEAP Technologies on how we can help you get maximized throughput with flexible pipetting automation solutions.

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For additional information about LEAP and the PAL Platform, please contact LEAP Technologies.

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