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Revision as of 15:17, 6 May 2010

Welcome to the LEAP Technologies wiki, a digital brochure of LEAP applications.

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 ↳ leapwiki.com

Company Description

LEAP Technologies, Inc. was founded in 1989 as an autosampler company serving the GC and GC–MS markets. Since then, LEAP has expanded into front-end sample handling for all areas of chromatography and mass spectroscopy, including LC/MS/MS and MALDI-MS as well as robotics for proteomics and fiber optic UV technology for tablet dissolution. LEAP strives to find total solutions for analytical lab automation. One of the major components in LEAP's approach to automation solutions is with the PAL X,Y,Z robot.

The LEAP Story

LEAP is experienced in providing automation solutions for any process that gathers, treats and delivers samples to an analytical process. Liquid Handling is in most cases involved but we are not limited to that. We can also move,weigh and image objects. Liquid handling includes spraying and printing besides the usual measuring, pipetting, injecting, mixing , heating or sampling of a variety of liquids. We have the ability to design, engineer, deliver and support simple but unique or complex but simple to use systems. The LEAP Shell software lets us create solution-specific sample lists and shell methods that synchronize all instruments involved. LEAP Shell is used for LC/LCMS and stand-alone workstations. LEAP uses Chronos Mastersoftwarefor GC and GC-MS integrations. Currently, Chronos integrates with Thermo Electron Xcalibur 1.4 and 2.0 GC & Agilent GC and MSD ChemStation. Further data system packages are begin integrate with Chronos so check with LEAP to see if your is.
We can provide complete locked-down systems to Value Added Resellers (VARs). Combinations of instruments that we can supply are robotic sampling devices and LC pumps as front-end to LC-MS systems. Single and dual channel LC to one MS that save cycle time and therefore increase throughput are becoming standard Frontend Automation Bundles (FABs). LEAP has available a proven SDK for PAL integration into your data system software.
One of LEAP's fundamental business philosophies is to build strong client relationships by knowing our customers and responding to their specific needs with superior personal service whether you have one PAL or are VAR of LEAP's.

Chief Chromatographic Techniques Supported:

• LC-Fraction Collection for purification(semi-prep)
• LC–MS Sample Handlers providing sample just before injection
• GC and GC–MS Sample Prep such as Headspace,SPME, 96-well Filtration, ITSP,MEPS SPEwith different injection techniques
• LC pumps for 50nl-2ml flow rates applicable to standard, micro and capillary columns
• 2D LC systems with sample handlers (PAL) for nano spray, nano fractionation to MALDI and other fraction collection schemes

A Sampling of Markets Served:

• Pharma / Biotech
• Polymer / Chemical
• Proteomics
• Forensic
• Food and Beverage
• Fragrance
• Environmental

Application Solutions

Application Solutions

LEAP strives to find standardized solutions creating the total package for all industries using analytical processes for small and large molecules in extracted liquids, solids, and in human, animal and plant tissues. We provide the precise robotics and efficient sample prep required by modern measurement techniques such as mass spectroscopy. For more details, contact the LEAP office.

• Analyzing a Plant Extract

• Balance PAL

• Biofuel Applications

• Direct Analysis in Real Time (DART®)

• GC Headspace

• Filtering of Samples

• Hydrogen Deuterium Exchange

• LC Multi-Valve Applications

• MALDI Applications

• NMR Sample Prep

• Polymer Analysis

• Process Monitoring Applications

• Purification Applications

• Radiolabeling

• Semi Solid Applications

• Small Volume Fraction Collection

• Solid Phase Extraction

• SPME

• Tobacco Analysis

LEAP Integrated Components

Accessories
PAL Accessories and Options - a concept you can grow with for your CTC Analytics Autosampler. For more details, contact the LEAP office.

• Bar Code Reading

• Column Heating

• Cooling and Heating Sample Storage

• Filtering of Samples

• Headspace

• Large Volume Dispensing

• Mixing of Samples

• Unique Storage

• Unique Injections

• Valve Washing

Examples of Special Solutions

Example Solutions

Examples of some customized applications we have provided. We call them "LEAP Specials". They are custom made to suit your exact needs. Let us show you how automation can make your life in the laboratory easier, more efficient, and more rewarding. Turn Your CTC Autosampler into a LEAP WorkStation. The CTC PAL is a great autosampler but LEAP can improve upon it with one or more of our automated solutions. LEAP is experienced in providing automation solutions for any process that gathers, treats and delivers samples to an analytical process. Liquid Handling is in most cases involved but we are not limited to that. We can also move, weigh and image objects. Liquid handling includes spraying and printing besides the usual measuring, pipetting, injecting, mixing, heating or sampling of a variety of liquids. We have the ability to design, engineer, deliver and support simple but unique or complex but simple to use systems. We have various software packages to choose from including all major data systems. Our own LEAP Shell scheduling software let’s us create solution specific sample lists and Shell methods that synchronizes all instruments involved. We also can use Chronos Mastersoftware, Cycle Composer software, Cycle Editor and ICC-CE depending on your needs.
For more details, contact the LEAP office and provide the project code.

• Analysis of Total Iodine

• A Flexible LCMS Front End for High-Throughput Bioanalytical Analysis in GLP Environment

• Automated online liquid chromatographic/mass spectrometric metabolic study for prodrug stability

• Detecting a Carcinogen in Alcohol Beverages

• Dilute and incubate sample prior to LC injection

• Dual Channel Sample Cleanup

• Forced Degradation

• Forced Degradation - Dual PAL under LEAP Shell

• High SPEed for CTC PAL On-line Multidimensional SPE-SPE-LC of Raw Biofluids

• High Throughput Sample Analysis using Multiple Column LC/MS/MS and Automated Method Optimization Techniques

• Intrinsic Viscosity testing

• Increasing throughput of parallel on-line extraction liquid chromatography/electrospray ionization tandem mass spectrometry system for GLP quantitative bioanalysis in drug development

• Integrated high capacity solid phase extraction-MS/MS system for pharmaceutical profiling in drug discovery

• Kinetic Reaction with GC Injection

• Mass Spec based Purification System

• Measuring nicotine partitioning from a tobacco smoke filter pad in an ammonia environment

• Multiplexing LC injections

• Multi-Valve system for selectable loop size

• One Step Derivitization

• Online Sample Cleanup using column switching with Multi-Valve system

• On-line SPE LC/MS/MS to Detect Organonitrogen and Triazine Pesticides in Drinking Water

• Pooling of vial contents for QC testing

• Productivity Package

• Rapid Precision Dispensing

• Sample Filtration with LEAP X-Press

• Sandwich Technique for Small Sample Volumes

• Sharper peaks using 2-stage low sample dispersal injection technique

• Simultaneous Screen of 23 Drugs of Abuse by LC API MS MS

• Static Headspace Gas Chromatography – Mass Spectrometry(SHS-GC–MS) Method for Monitoring the Formation of ethyl methane sulfonate from ethanol and methane sulfonic acid

• Tobacco Filtration - 96 Well Plate Filtration

• Tobacco Filtration - Large Volume Flask

• Twin PAL - High Throughput injections using Cycle Composer

• Using the PAL Autosampler as a Syringe Pump for MS Tuning

Search LEAP Wiki

Search LEAP Wiki

5 Things you may not know about the PAL

Five things about the PAL

Glossary

Glossary

Videos

Videos of PAL Robot on YouTube

Consumables

Consumables

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LEAP Technologies provides fully automated sample processing workstation instrumentation solutions based on the LEAP CTC PAL X, Y, Z syringe only autosampler robot. This extremely flexible, precise, and adaptable liquid handling robotic platform is available in a variety of lengths and options depending on the requirements of your sample preparation and injections for your UHPLC, LC or GC chromatography. LEAP also offers process control systems and stand alone workstations. LEAP offers full support and service for the PAL platform with over 10 years of history with the PAL. LEAP can also write custom macros, cycles, and scheduling software for your specific applications. We're proud that LEAP is known as a productivity improver for laboratories including government labs in agencies such as FDA, USDA, EPA, FBI, Armed Forces, Homeland Security and others function more efficiently. Robotic sample prep equipment works well in government labs and challenges lab technicians to keep feeding those more samples. Analytical equipment such as chromatographs and mass spectrometers are expensive devices and also expensive to maintain. LEAP can help to keep them running and analyze samples around the clock. LEAP has most of its laboratory automation robots under GSAcontract and is eager to service and maintain everything it sells to keep your expensive lab equipment running around the clock.
Please contact LEAP Technologies on how we can help you get maximized throughput with flexible pipetting automation solutions whether it is our standard applications or customized to your needs. LEAP provides automation that fits your needs and reduces errors, increases sample capacity, increases efficiency, reduces cost by supplying long term productivity improvements with user friendly software and flexible hardware.

Contact LEAP

Contact LEAP For additional information about LEAP and the PAL Platform, please contact LEAP Technologies.

The information and references contained in this web site are believed to be accurate and the most current information available.