Main Page

From LEAP

Revision as of 16:33, 9 June 2009 (view source) Bpeat (Talk | contribs) (→Examples of Special Solutions) ← Older edit		Revision as of 17:59, 9 June 2009 (view source) Bpeat (Talk | contribs) (→Examples of Special Solutions) Newer edit →
Line 133:		Line 133:
	*[[Pooling of vial contents for QC testing]]		*[[Pooling of vial contents for QC testing]]
		+
		+	*[[Productivity_Package]]
	*[[Rapid Precision Dispensing]]		*[[Rapid Precision Dispensing]]

---

Revision as of 17:59, 9 June 2009

Welcome to the LEAP Technologies wiki, a digital brochure of LEAP applications.

Contents 1 Company Description 2 The LEAP Story 3 Application Solutions 4 LEAP Integrated Components 5 Examples of Special Solutions 6 Glossary 7 Videos 8 Contact LEAP

Company Description

LEAP Technologies, Inc. was founded in 1989 as an autosampler[1] company serving the GC and GC–MS markets. Since then, LEAP has expanded into front-end sample handling for all areas of chromatography and mass spectroscopy, including LC/MS/MS and MALDI-MS as well as robotics for proteomics and fiber optic UV technology for tablet dissolution. LEAP strives to find total solutions for analytical lab automation. One of the major components in LEAP's approach to automation solutions is with the PAL[2] X,Y,Z robot.

The LEAP Story

LEAP is experienced in providing automation solutions for any process that gathers, treats and delivers samples to an analytical process. Liquid Handling is in most cases involved but we are not limited to that. We can also move, weigh and image objects. Liquid handling includes spraying and printing besides the usual measuring, pipetting, injecting, mixing, heating or sampling of a variety of liquids. We have the ability to design, engineer, deliver and support simple but unique or complex but simple to use systems. The LEAP Shell 3[3] software lets us create solution-specific sample lists and Shell 3 methods that synchronize all instruments involved. We can provide complete locked-down systems to Value Added Resellers (VARs). Combinations of instruments that we can supply are robotic sampling devices and LC pumps as front-end to LC-MS systems. Single and dual channel LC to one MS that save cycle time and therefore increase throughput are becoming standard Frontend Automation Bundles (FABs).

Chief Chromatographic Techniques Supported:

• LC-Fraction Collection for purification (semi-prep)
• LC–MS Sample Handlers providing sample just before injection
• GC and GC–MS Sample Prep such as headspace, SPME, and 96-well SPE with different injection techniques
• LC pumps for 50nl-2ml flow rates applicable to standard, micro and capillary columns
• 2D LC systems with sample handlers (PALs) for nano spray, nano fractionation to MALDI and other fraction collection schemes

Markets Served:

• Pharma / Biotech
• Polymer / Chemical
• Proteomics
• Forensic
• Food and Beverage
• Fragrance
• Environmental

Application Solutions

LEAP strives to find solutions for all industries using analytical processes for small and large molecules in extracted liquids, solids, and in human, animal and plant tissues. We provide the precise robotics and efficient sample prep required by modern measurement techniques such as mass spectroscopy.

• Analyzing a Plant Extract

• Balance PAL

• Biofuel Applications

• Direct Analysis in Real Time (DART®)

• GC Headspace

• Filtering of Samples

• Hydrogen Deuterium Exchange

• LC Multi-Valve Applications

• MALDI Applications

• NMR Sample Prep

• Polymer Analysis

• Process Monitoring Applications

• Purification Applications

• Small Volume Fraction Collection

• Solid Phase Extraction

• SPME

LEAP Integrated Components

PAL Accessories and Options - a concept you can grow with for your CTC Autosampler

For individual categories please go to Category Accessories

• Bar Code Reading

• Column Heating

• Cooling and Heating Sample Storage

• Filtering of Samples

• Large Volume Dispensing

• Mixing of Samples

• Unique Storage

• Unique Injections

• Valve Washing

Examples of Special Solutions

Examples of some customized applications we have provided. We call them "LEAP Specials". They are custom made to suit your exact needs. Let us show you how automation can make your life in the laboratory easier, more efficient, and more rewarding. Turn Your CTC Autosampler into a LEAP WorkStation. The CTC PAL is a great autosampler but LEAP can improve upon it with one or more of our automated solutions. LEAP is experienced in providing automation solutions for any process that gathers, treats and delivers samples to an analytical process. Liquid Handling is in most cases involved but we are not limited to that. We can also move, weight and image objects. Liquid handling includes spraying and printing besides the usual measuring, pipetting, injecting, mixing, heating or sampling of a variety of liquids. We have the ability to design, engineer, deliver and support simple but unique or complex but simple to use systems. We have various software packages to choose from including all major datasystems. Our own LEAP Shell 3 scheduling software let’s us create solution specific sample lists and Shell 3 methods that synchronizes all instruments involved.

For more details, contact the LEAP office and provide the project code.

• Analysis of Total Iodine

• A Flexible LCMS Front End for High-Throughput Bioanalytical Analysis in GLP Environment

• Automated online liquid chromatographic/mass spectrometric metabolic study for prodrug stability

• Detecting a Carcinogen in Alcohol Beverages

• Dilute and incubate sample prior to LC injection

• Dual Channel Sample Cleanup

• Forced Degradation - Dual PAL under LEAP Shell

• High SPEed for CTC PAL On-line Multidimensional SPE-SPE-LC of Raw Biofluids

• High Throughput Sample Analysis using Multiple Column LC/MS/MS and Automated Method Optimization Techniques

• Intrinsic Viscosity testing

• Increasing throughput of parallel on-line extraction liquid chromatography/electrospray ionization tandem mass spectrometry system for GLP quantitative bioanalysis in drug development

• Integrated high capacity solid phase extraction-MS/MS system for pharmaceutical profiling in drug discovery

• Kinetic Reaction with GC Injection

• Multiplexing LC injections

• Multi-Valve system for selectable loop size

• One Step Derivitization

• Online Sample Cleanup using column switching with Multi-Valve system

• On-line SPE LC/MS/MS to Detect Organonitrogen and Triazine Pesticides in Drinking Water

• Pooling of vial contents for QC testing

• Productivity_Package

• Rapid Precision Dispensing

• Sample Filtration with Whatman Mini-Uniprep Press

• Sandwich Technique for Small Sample Volumes

• Sharper peaks using 2-stage low sample dispersal injection technique

• Simultaneous Screen of 23 Drugs of Abuse by LC API MS MS

• Twin PAL - High Throughput injections using Cycle Composer

• Using the PAL Autosampler as a Syringe Pump for MS Tuning

---

Glossary

Glossary

---

Videos

Videos of PAL Robot on YouTube

---

Contact LEAP

For additional information about this technique please contact LEAP Technologies for detailed information

Contact the LEAP office