Summary of LC Multi Valve Applications

(Difference between revisions)

Revision as of 20:56, 11 May 2009

	LC Multiple Valve Applications
	Application Type
	STANDARD AND SPECIAL
	Application ID

	Description
	Multiple Valve Applications for LC

Code	Application	Control SW	Key Hardware	Key Benefits	Restrictions	GLP
M-001 [1]	Dual Channel Serial Injection Provides shorter cycle times by regenerating columns during next analytical run	Analyst with ICC-CE	* 6 port injection valve * 10 port Valve * Gradient Pump * Regeneration pump	* Saving of regeneration time(Back Cut) * Increase throughput at little cost * Control is all within Analyst * Compliance is not affected	* Can not do "Look Ahead" * Injections are not staggered * Peaks of interest must come of early * Columns may perform slightly differently on alternating samples	Yes

Code	Application	Control SW	Key Hardware	Key Benefits	Restrictions	GLP
M-002 [2]	Dual Channel Serial Injection with Front Cut Provides shorter cycle times by regenerating columns during next analytical run and diverts the solvent front to waste	Analyst with ICC-CE	* Trio VS * Gradient Pump * Regeneration pump	* Saving of regeneration time(Back Cut) * Increase throughput at little cost * Control is all within Analyst * Compliance is not affected * Avoids contaminating MS inlet with early eluting compounds and solvent	* Can not do "Look Ahead" * Injections are not staggered * Peaks of interest must come of early * Columns may perform slightly differently on alternating samples	Yes

Code	Application	Control SW	Key Hardware	Key Benefits	Restrictions	GLP
M-003 [3]	Dual Channel Parallel Injection Provides shorter cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition	Cycle Composer outside of Analyst	* DoubleStack valve * 6 port injection valve * FWS in front of 6 port valve * Gradient Pump * Regeneration pump	* Saving of Front and Back Cut * Provides "Look Ahead" * Provides staggering of injections	* Requires matching sample lists in Cycle Composer and Analyst * Columns may perform slightly differently on alternating samples	No

Code	Application	Control SW	Key Hardware	Key Benefits	Restrictions	GLP
M-004	Analyst with "Look Ahead" with LEAP Shell Control of the Sample List is through LEAP Shell	LEAP Shell	* Standard PAL * Pumps are supported within Analyst	* "look Ahead" * Can import custom columns * Freedom to create and use custom Cycles	* Does not support 21CFR11 compliance * Requires pumps to be integrated with LEAP Shell	No

Code	Application	Control SW	Key Hardware	Key Benefits	Restrictions	GLP
M-005 [4]	Dual Channel Parallel Injection Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition	LEAP Shell	* DoubleStack valve * 6 port injection valve * FWS in front of 6 port valve * Gradient Pump * Regeneration pump	* Integration with Analyst Software * Single Sample List * Provides staggering of injections * Multiplexes 2 separate LC systems into on MS	* Does not support 21CFR11 compliance * Requires pumps to be integrated with LEAP Shell	No

Code	Application	Control SW	Key Hardware	Key Benefits	Restrictions	GLP
M-006 [5]	Inline Sample Concentration SPE Column regenerated during analytical extraction	Analyst with ICC-CE	* TrioVS	* Automated concentration and elution of sample on SPE column prior to separation on analytical column	* No "Look Ahead" * Can not prep samples ahead of analytical run	No

Code	Application	Control SW	Key Hardware	Key Benefits	Restrictions	GLP
M-007 [6]	Inline Sample Filtration SPE Column regenerated during analytical extraction	Analyst with ICC-CE	* TrioVS	* Automated filtration of sample on cleanup column prior to separation on analytical column	* No "Look Ahead" * Can not prep samples ahead of analytical run	No

Code	Application	Control SW	Key Hardware	Key Benefits	Restrictions	GLP
M-008 [7]	Dual Channel In-line Sample Concentration SPE Column regenerated during analytical extraction	Cycle Composer outside of Analyst	* TrioVS	* Dual Stream * High throughput sample cleanup "Look Ahead"	* Requires two matching sample lists	No

Code	Application	Control SW	Key Hardware	Key Benefits	Restrictions	GLP
M-009 [8]	Dual Channel in-line Sample Filtration SPE Column regenerated during analytical extraction	Cycle Composer outside of Analyst	* TrioVS	* Dual Stream * High throughput sample cleanup * "Look Ahead"	* Requires two matching sample lists	No

Code	Application	Control SW	Key Hardware	Key Benefits	Restrictions	GLP
M-010 [9]	Dual Channel in-line Sample Concentration SPE Column regenerated during analytical extraction	LEAP Shell	* TrioVS	* High throughput sample cleanup "Look Ahead"		No

Code	Application	Control SW	Key Hardware	Key Benefits	Restrictions	GLP
M-011 [10]	Dual Channel in-line Sample Filtration SPE Column regenerated during analytical extraction	LEAP Shell	* TrioVS	* High throughput sample cleanup "Look Ahead"		No

Code	Application	Control SW	Key Hardware	Key Benefits	Restrictions	GLP
M-014 [11]	Selectable HPLC (max 2 Streams)	Analyst Standard Cycles	* Two Injection Valves * MS Stream Selector	* Different Analyst Methods inject into different LC Valves * Uses Standard Analyst cycles	* Requires Analyst control of the stream selector valve * Max of 2 streams can be supported	Yes

Code	Application	Control SW	Key Hardware	Key Benefits	Restrictions	GLP
M-015 [12]	Selectable HPLC (max 4 Streams)	Analyst with ICC-CE	* Multiple Injection Valves (serial control) * PAL 10 port Valve for Stream Selector	* Different Analyst Methods inject into different LC Valves * Stream selection to MS	* PAL controls the stream selector valve * Requires Custom Cycle	Yes

Code	Application	Control SW	Key Hardware	Key Benefits	Restrictions	GLP
M-016 [13]	Column Selection Method selects which HPLC column is in-line before injection	Analyst with ICC-CE	* CTC Column Selector * Up to 5 columns	* Automated switching between analytical columns within run	* Requires Custom Cycles	Yes

LEAP offers multiple choices of Valve Self Wash Stations to aid in cleaning the valve [14]
LEAP Shell Software and application for custom injections and scheduling [15]

www.leaptec.com
www.leapwiki.com

For additional information about this technique please contact LEAP Technologies for detailed information

@@ Line 64: / Line 64: @@
 | style="border:1px solid blue;"|* Saving of Front and Back Cut<br>* Provides "Look Ahead"<br> * Provides staggering of injections
 | style="border:1px solid blue;"|* Requires matching sample lists in Cycle Composer and Analyst<br>* Columns may perform slightly differently on alternating samples
+| style="border:1px solid blue;"|No
+|}
+<br>
+{| cellpadding="6" style="border:1px solid darkgray;"
+|- align=left
+!width="20"|Code
+!width="195"|Application
+!width="85"|Control SW
+!width="140"|Key Hardware
+!width="205"|Key Benefits
+!width="235"|Restrictions
+!width="15"|GLP
+|- align=left
+| style="border:1px solid blue;"|'''M-004'''
+| style="border:1px solid blue;"|'''Analyst with "Look Ahead" with LEAP Shell'''<br><br>Control of the Sample List is through LEAP Shell
+| style="border:1px solid blue;"|LEAP Shell
+| style="border:1px solid blue;"|* Standard PAL <br>* Pumps are supported within Analyst
+| style="border:1px solid blue;"|* "look Ahead" <br> * Can import custom columns<br> * Freedom to create and use custom Cycles
+| style="border:1px solid blue;"|* Does not support 21CFR11 compliance<br>* Requires pumps to be integrated with LEAP Shell
 | style="border:1px solid blue;"|No
 |}