Summary of LC Multi Valve Applications
From LEAP
| LC Multiple Valve Applications |
| Application Type | |
| STANDARD AND SPECIAL | |
| Application ID | |
| Description | |
| Multiple Valve Applications for LC |
Specific Categories
There are many techniques and applications that LEAP Technologies can help you with to increase sample throughput with automated injection HPLC and UPLC systems. From "Front Cuts" to "Heart Cuts" to "Back Cuts" to "Multiplexing". Typical applications are pre-column SPE, pre-column cleanup, sample desalting,parallel column regeneration, etc. LEAP has the experience to solve your throughput needs. These are just a few of our offerings. We integrate multiple vendors HPLC systems and have a wide array of injection valves and selector valves to get you the best result. Many of these can be added to your existing systems to better utilize the hardware you already have with some additional valve switching modules from LEAP Technologies.
| Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
|---|---|---|---|---|---|---|
| M-001 | Dual Channel Serial Injections Provides shorter cycle times by regenerating columns during next analytical run | Analyst with ICC-CE | * 6 port injection valve * 10 port Valve * Gradient Pump * Regeneration pump | * Saving of regeneration time(Back Cut) * Increase throughput at little cost * Control is all within Analyst * Compliance is not affected | * Can not do "Look Ahead" * Injections are not staggered * Peaks of interest must come of early * Columns may perform slightly differently on alternating samples | Yes |
| Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
|---|---|---|---|---|---|---|
| M-002 | Dual Channel Serial Injection with Front Cut Provides shorter cycle times by regenerating columns during next analytical run and diverts the solvent front to waste | Analyst with ICC-CE | * Trio VS * Gradient Pump * Regeneration pump | * Saving of regeneration time(Back Cut) * Increase throughput at little cost * Control is all within Analyst * Compliance is not affected * Avoids contaminating MS inlet with early eluting compounds and solvent | * Can not do "Look Ahead" * Injections are not staggered * Peaks of interest must come of early * Columns may perform slightly differently on alternating samples | Yes |
| Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
|---|---|---|---|---|---|---|
| M-003 | Dual Channel Parallel Injection Provides shorter cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition | Cycle Composer outside of Analyst | * DoubleStack valve * 6 port injection valve * FWS in front of 6 port valve * Gradient Pump * Regeneration pump | * Saving of Front and Back Cut * Provides "Look Ahead" * Provides staggering of injections | * Requires matching sample lists in Cycle Composer and Analyst * Columns may perform slightly differently on alternating samples | No |
| Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
|---|---|---|---|---|---|---|
| M-004 | Analyst with "Look Ahead" with LEAP Shell Control of the Sample List is through LEAP Shell | LEAP Shell | * Standard PAL * Pumps are supported within Analyst | * "Look Ahead" * Can import custom columns * Freedom to create and use custom Cycles | * Does not support 21CFR11 compliance | No |
| Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
|---|---|---|---|---|---|---|
| M-005 | Dual Channel Parallel Injection Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition | LEAP Shell | * DoubleStack valve * 6 port injection valve * FWS in front of 6 port valve * Gradient Pump * Regeneration pump | * Integration with Analyst Software * Single Sample List * Provides staggering of injections * Multiplexes 2 separate LC systems into on MS | * Does not support 21CFR11 compliance * Requires pumps to be integrated with LEAP Shell | No |
| Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
|---|---|---|---|---|---|---|
| M-006 | Inline Sample Concentration SPE Column regenerated during analytical extraction | Analyst with ICC-CE | * TrioVS | * Automated concentration and elution of sample on SPE column prior to separation on analytical column | * No "Look Ahead" * Can not prep samples ahead of analytical run | No |
| Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
|---|---|---|---|---|---|---|
| M-007 | Inline Sample Filtration SPE Column regenerated during analytical extraction | Analyst with ICC-CE | * TrioVS | * Automated filtration of sample on cleanup column prior to separation on analytical column | * No "Look Ahead" * Can not prep samples ahead of analytical run | No |
| Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
|---|---|---|---|---|---|---|
| M-008 | M-008 Dual Channel In-line Sample Concentration SPE Column regenerated during analytical extraction | Cycle Composer outside of Analyst | * TrioVS | * Dual Stream * High throughput sample cleanup "Look Ahead" | * Requires two matching sample lists | No |
| Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
|---|---|---|---|---|---|---|
| M-009 | Dual Channel in-line Sample Filtration SPE Column regenerated during analytical extraction | Cycle Composer outside of Analyst | * TrioVS | * Dual Stream * High throughput sample cleanup * "Look Ahead" | * Requires two matching sample lists | No |
| Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
|---|---|---|---|---|---|---|
| M-010 | Dual Channel in-line Sample Concentration SPE Column regenerated during analytical extraction | LEAP Shell | * TrioVS | * High throughput sample cleanup "Look Ahead" | No |
| Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
|---|---|---|---|---|---|---|
| M-011 | Dual Channel in-line Sample Filtration SPE Column regenerated during analytical extraction | LEAP Shell | * TrioVS | * High throughput sample cleanup "Look Ahead" | No |
| Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
|---|---|---|---|---|---|---|
| M-014 | Selectable HPLC (max 2 Streams) | Analyst Standard Cycles | * Two Injection Valves * MS Stream Selector | * Different Analyst Methods inject into different LC Valves * Uses Standard Analyst cycles | * Requires Analyst control of the stream selector valve * Max of 2 streams can be supported | Yes |
| Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
|---|---|---|---|---|---|---|
| M-015 | Selectable HPLC (max 4 Streams) | Analyst with ICC-CE | * Multiple Injection Valves (serial control) * PAL 10 port Valve for Stream Selector | * Different Analyst Methods inject into different LC Valves * Stream selection to MS | * PAL controls the stream selector valve * Requires Custom Cycle | Yes |
| Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
|---|---|---|---|---|---|---|
| M-016 | Column Selection Method selects which HPLC column is in-line before injection | Analyst with ICC-CE | * CTC Column Selector * Up to 5 columns | * Automated switching between analytical columns within run | * Requires Custom Cycles | Yes |
Why invest in Multi-Valve Applications?
- More through-put
- Faster gradient
- Pre-separation, SPE with better detection
- Keep detector system clean
- Convenience
- Controlled from one software
- Support
Videos
LEAP's PAL Application Videos on YouTube
Print
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For other cost/time saving measures consider:
- LEAP offers multiple choices of Valve Self Wash Stations to aid in cleaning the valve
- LEAP offers custom sample prep and inject with Analyst and other data systems
- LEAP Shell Software and application for custom injections and scheduling
LEAP provides automated workstation instrumentation solutions based on the LEAP CTC PAL X, Y, Z syringe only autosampler robot from LEAP Technologies. This extremely flexible, precise, and adaptable liquid handling robotic platform is available in a variety of lengths and options depending on the requirements of your sample preparation and injections for your UHPLC, LC or GC chromatography.LEAP offers full support and service for the PAL platform in addition to being able to write custom macros, cycles, and scheduling to your applications. Please contact LEAP Technologies on how we can help you get maximized throughput with flexible pipetting automation solutions.
Contact LEAP
Contact the LEAP office
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