Summary of LC Multi Valve Applications
From LEAP
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| - | | style="border:1px solid blue;"|'''M-001''' | + | | style="border:1px solid blue;"|'''M-001'''[http://www.leapwiki.com/mediawiki/index.php?title=M-001_Dual_Channel_Serial_Injection_-_Analyst_with_ICC-CE] |
| style="border:1px solid blue;"|'''Dual Channel Serial Injection'''<br><br>Provides shorter cycle times by regenerating columns during next analytical run | | style="border:1px solid blue;"|'''Dual Channel Serial Injection'''<br><br>Provides shorter cycle times by regenerating columns during next analytical run | ||
| style="border:1px solid blue;"|Analyst with ICC-CE | | style="border:1px solid blue;"|Analyst with ICC-CE | ||
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| style="border:1px solid blue;"|* Saving of Front and Back Cut<br>* Provides "Look Ahead"<br> *Provides staggering of injections | | style="border:1px solid blue;"|* Saving of Front and Back Cut<br>* Provides "Look Ahead"<br> *Provides staggering of injections | ||
| style="border:1px solid blue;"|* Requires matching sample lists in Cycle Composer and Analyst<br>* Columns may perform slightly differently on alternating samples | | style="border:1px solid blue;"|* Requires matching sample lists in Cycle Composer and Analyst<br>* Columns may perform slightly differently on alternating samples | ||
| + | | style="border:1px solid blue;"|No | ||
| + | |} | ||
| + | <br> | ||
| + | {| cellpadding="6" style="border:1px solid darkgray;" | ||
| + | |- align=left | ||
| + | !width="20"|Code | ||
| + | !width="195"|Application | ||
| + | !width="85"|Control SW | ||
| + | !width="140"|Key Hardware | ||
| + | !width="205"|Key Benefits | ||
| + | !width="235"|Restrictions | ||
| + | !width="15"|GLP | ||
| + | |- align=left | ||
| + | | style="border:1px solid blue;"|'''M-005''' | ||
| + | | style="border:1px solid blue;"|'''Dual Channel Parallel Injection'''<br><br>Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition | ||
| + | | style="border:1px solid blue;"|LEAP Shell | ||
| + | | style="border:1px solid blue;"|*DoubleStack valve<br>*6 port injection valve<br>*FWS in front of 6 port valve<br>* Gradient Pump<br>* Regeneration pump | ||
| + | | style="border:1px solid blue;"|*Integration with Analyst Software<br>*Single Sample List<br> *Provides staggering of injections<br> *Multiplexes 2 separate LC systems into on MS | ||
| + | | style="border:1px solid blue;"|* Does not support 21CFR11 compliance<br>*Requires pumps to be integrated with LEAP Shell | ||
| style="border:1px solid blue;"|No | | style="border:1px solid blue;"|No | ||
|} | |} | ||
Revision as of 19:36, 11 May 2009
| LC Multiple Valve Applications |
| Application Type | |
| STANDARD AND SPECIAL | |
| Application ID | |
| Description | |
| Multiple Valve Applications for LC |
| Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
|---|---|---|---|---|---|---|
| M-001[1] | Dual Channel Serial Injection Provides shorter cycle times by regenerating columns during next analytical run | Analyst with ICC-CE | * 6 port injection valve * 10 port Valve * Gradient Pump * Regeneration pump | * Saving of regeneration time(Back Cut) * Increase throughput at little cost * Control is all within Analyst * Compliance is not affected | * Can not do "Look Ahead" * Injections are not staggered * Peaks of interest must come of early * Columns may perform slightly differently on alternating samples | Yes |
| Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
|---|---|---|---|---|---|---|
| M-002 | Dual Channel Serial Injection with Front Cut Provides shorter cycle times by regenerating columns during next analytical run and diverts the solvent front to waste | Analyst with ICC-CE | * Trio VS * Gradient Pump * Regeneration pump | * Saving of regeneration time(Back Cut) * Increase throughput at little cost * Control is all within Analyst * Compliance is not affected * Avoids contaminating MS inlet with early eluting compounds and solvent | * Can not do "Look Ahead" * Injections are not staggered * Peaks of interest must come of early * Columns may perform slightly differently on alternating samples | Yes |
| Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
|---|---|---|---|---|---|---|
| M-003 | Dual Channel Parallel Injection Provides shorter cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition | Cycle Composer outside of Analyst | * DoubleStack valve *6 port injection valve *FWS in front of 6 port valve * Gradient Pump * Regeneration pump | * Saving of Front and Back Cut * Provides "Look Ahead" *Provides staggering of injections | * Requires matching sample lists in Cycle Composer and Analyst * Columns may perform slightly differently on alternating samples | No |
| Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
|---|---|---|---|---|---|---|
| M-005 | Dual Channel Parallel Injection Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition | LEAP Shell | *DoubleStack valve *6 port injection valve *FWS in front of 6 port valve * Gradient Pump * Regeneration pump | *Integration with Analyst Software *Single Sample List *Provides staggering of injections *Multiplexes 2 separate LC systems into on MS | * Does not support 21CFR11 compliance *Requires pumps to be integrated with LEAP Shell | No |
| Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
|---|---|---|---|---|---|---|
| M-005 | Dual Channel Parallel Injection Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition | LEAP Shell | *DoubleStack valve *6 port injection valve *FWS in front of 6 port valve * Gradient Pump * Regeneration pump | *Integration with Analyst Software *Single Sample List *Provides staggering of injections *Multiplexes 2 separate LC systems into on MS | * Does not support 21CFR11 compliance *Requires pumps to be integrated with LEAP Shell | No |
For other cost/time saving measures consider:
- LEAP offers multiple choices of Valve Self Wash Stations to aid in cleaning the valve [2]
- Dual Channel Serial Injection (M-001) using Analyst and ICC-CE [3]
- Dual Channel Serial Injection with Front Cut (M-002) using Analyst and ICC-CE [4]
- Dual Channel Parallel Injection (M-003) using Cycle Composer Software and Analyst [5]
- “Look Ahead”, sample prep before injection (M-004) using LEAP Shell Software [6]
- Dual Channel Parallel Injection (M-005) using LEAP Shell software [7]
- LEAP Shell Software and application for custom injections and scheduling [8]
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Contact LEAP
For additional information about this technique please contact LEAP Technologies for detailed information
