Summary of LC Multi Valve Applications

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-	|type        = '''Multi Valves'''	+	|type        = '''STANDARD AND SPECIAL'''
-	|id          = ABC	+	|id          =
-	|description = HPLC Multi Vale Applications	+	|description = Multiple Valve Applications for LC
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Revision as of 12:16, 9 May 2009

	LC Multiple Valve Applications
	Application Type
	STANDARD AND SPECIAL
	Application ID
	Description
	Multiple Valve Applications for LC

Code	Application	Control SW	Key Hardware	Key Benefits	Restrictions	GLP
M-001	Dual Channel Serial Injection Provides shorter cycle times by regenerating columns during next analytical run	Analyst with ICC-CE	* 6 port injection valve * 10 port Valve * Gradient Pump * Regeneration pump	* Saving of regeneration time(Back Cut) * Increase throughput at little cost * Control is all within Analyst * Compliance is not affected	* Can not do "Look Ahead" * Injections are not staggered * Peaks of interest must come of early * Columns may perform slightly differently on alternating samples	Yes

Code	Application	Control SW	Key Hardware	Key Benefits	Restrictions	GLP
M-002	Dual Channel Serial Injection with Front Cut Provides shorter cycle times by regenerating columns during next analytical run and diverts the solvent front to waste	Analyst with ICC-CE	* Trio VS * Gradient Pump * Regeneration pump	* Saving of regeneration time(Back Cut) * Increase throughput at little cost * Control is all within Analyst * Compliance is not affected * Avoids contaminating MS inlet with early eluting compounds and solvent	* Can not do "Look Ahead" * Injections are not staggered * Peaks of interest must come of early * Columns may perform slightly differently on alternating samples	Yes

Code	Application	Control SW	Key Hardware	Key Benefits	Restrictions	GLP
M-003	Dual Channel Parallel Injection Provides shorter cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition	Cycle Composer outside of Analyst	* DoubleStack valve *6 port injection valve *FWS in front of 6 port valve * Gradient Pump * Regeneration pump	* Saving of Front and Back Cut * Provides "Look Ahead" *Provides staggering of injections	* Requires matching sample lists in Cycle Composer and Analyst * Columns may perform slightly differently on alternating samples	No

Code	Application	Control SW	Key Hardware	Key Benefits	Restrictions	GLP
M-005	Dual Channel Parallel Injection Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition	LEAP Shell	*DoubleStack valve *6 port injection valve *FWS in front of 6 port valve * Gradient Pump * Regeneration pump	*Integration with Analyst Software *Single Sample List *Provides staggering of injections *Multiplexes 2 separate LC systems into on MS	* Does not support 21CFR11 compliance *Requires pumps to be integrated with LEAP Shell	No

Code	Application	Control SW	Key Hardware	Key Benefits	Restrictions	GLP
M-005	Dual Channel Parallel Injection Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition	LEAP Shell	*DoubleStack valve *6 port injection valve *FWS in front of 6 port valve * Gradient Pump * Regeneration pump	*Integration with Analyst Software *Single Sample List *Provides staggering of injections *Multiplexes 2 separate LC systems into on MS	* Does not support 21CFR11 compliance *Requires pumps to be integrated with LEAP Shell	No

Code	Application	Control SW	Key Hardware	Key Benefits	Restrictions	GLP
M-005	Dual Channel Parallel Injection Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition	LEAP Shell	*DoubleStack valve *6 port injection valve *FWS in front of 6 port valve * Gradient Pump * Regeneration pump	*Integration with Analyst Software *Single Sample List *Provides staggering of injections *Multiplexes 2 separate LC systems into on MS	* Does not support 21CFR11 compliance *Requires pumps to be integrated with LEAP Shell	No

Code	Application	Control SW	Key Hardware	Key Benefits	Restrictions	GLP
M-005	Dual Channel Parallel Injection Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition	LEAP Shell	*DoubleStack valve *6 port injection valve *FWS in front of 6 port valve * Gradient Pump * Regeneration pump	*Integration with Analyst Software *Single Sample List *Provides staggering of injections *Multiplexes 2 separate LC systems into on MS	* Does not support 21CFR11 compliance *Requires pumps to be integrated with LEAP Shell	No

For other cost/time saving measures consider:

• LEAP offers multiple choices of Valve Self Wash Stations to aid in cleaning the valve [1]
• Dual Channel Serial Injection (M-001) using Analyst and ICC-CE [2]
• Dual Channel Serial Injection with Front Cut (M-002) using Analyst and ICC-CE [3]
• Dual Channel Parallel Injection (M-003) using Cycle Composer Software and Analyst [4]
• “Look Ahead”, sample prep before injection (M-004) using LEAP Shell Software [5]
• Dual Channel Parallel Injection (M-005) using LEAP Shell software [6]
• LEAP Shell Software and application for custom injections and scheduling [7]

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Contact LEAP

For additional information about this technique please contact LEAP Technologies for detailed information

• Contact the LEAP office