Summary of LC Multi Valve Applications

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| style="border:1px solid blue;"|* Different Analyst Methods inject into different LC Valves <br>* Uses Standard Analyst cycles
| style="border:1px solid blue;"|* Different Analyst Methods inject into different LC Valves <br>* Uses Standard Analyst cycles
| style="border:1px solid blue;"|* Requires Analyst control of the stream selector valve <br>* Max of 2 streams can be supported
| style="border:1px solid blue;"|* Requires Analyst control of the stream selector valve <br>* Max of 2 streams can be supported
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| style="border:1px solid blue;"|No
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| style="border:1px solid blue;"|Yes
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|}
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| style="border:1px solid blue;"|* Different Analyst Methods inject into different LC Valves <br>* Stream selection to MS
| style="border:1px solid blue;"|* Different Analyst Methods inject into different LC Valves <br>* Stream selection to MS
| style="border:1px solid blue;"|* PAL controls the stream selector valve <br>* Requires Custom Cycle
| style="border:1px solid blue;"|* PAL controls the stream selector valve <br>* Requires Custom Cycle
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| style="border:1px solid blue;"|No
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| style="border:1px solid blue;"|Yes
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|}
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{| cellpadding="6" style="border:1px solid darkgray;"
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|- align=left
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!width="20"|Code
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!width="195"|Application
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!width="85"|Control SW
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!width="140"|Key Hardware
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!width="205"|Key Benefits
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!width="235"|Restrictions
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!width="15"|GLP
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|- align=left
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| style="border:1px solid blue;"|'''M-016'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=Column_Selection]
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| style="border:1px solid blue;"|'''Column Selection'''<br><br> Method selects which HPLC column is in-line before injection
 +
| style="border:1px solid blue;"|Analyst with ICC-CE
 +
| style="border:1px solid blue;"|* CTC Column Selector <br>* Up to 5 columns
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| style="border:1px solid blue;"|* Automated switching between analytical columns within run
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| style="border:1px solid blue;"|* Requires Custom Cycles
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| style="border:1px solid blue;"|Yes
|}
|}
=== For other cost/time saving measures consider:===
=== For other cost/time saving measures consider:===

Revision as of 20:31, 11 May 2009

LC Multiple Valve Applications
Application Type
  STANDARD AND SPECIAL
Application ID
 
Description
  Multiple Valve Applications for LC


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-001
[1] 		Dual Channel Serial Injection

Provides shorter cycle times by regenerating columns during next analytical run 		Analyst with ICC-CE * 6 port injection valve
* 10 port Valve
* Gradient Pump
* Regeneration pump 		* Saving of regeneration time(Back Cut)
* Increase throughput at little cost
* Control is all within Analyst
* Compliance is not affected 		* Can not do "Look Ahead"
* Injections are not staggered
* Peaks of interest must come of early
* Columns may perform slightly differently on alternating samples 		Yes
Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-002
[2] 		Dual Channel Serial Injection with Front Cut

Provides shorter cycle times by regenerating columns during next analytical run and diverts the solvent front to waste 		Analyst with ICC-CE * Trio VS
* Gradient Pump
* Regeneration pump 		* Saving of regeneration time(Back Cut)
* Increase throughput at little cost
* Control is all within Analyst
* Compliance is not affected
* Avoids contaminating MS inlet with early eluting compounds and solvent 		* Can not do "Look Ahead"
* Injections are not staggered
* Peaks of interest must come of early
* Columns may perform slightly differently on alternating samples 		Yes


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-003
[3] 		Dual Channel Parallel Injection

Provides shorter cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition 		Cycle Composer outside of Analyst * DoubleStack valve
*6 port injection valve
* FWS in front of 6 port valve
* Gradient Pump
* Regeneration pump 		* Saving of Front and Back Cut
* Provides "Look Ahead"
* Provides staggering of injections 		* Requires matching sample lists in Cycle Composer and Analyst
* Columns may perform slightly differently on alternating samples 		No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-005
[4] 		Dual Channel Parallel Injection

Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition 		LEAP Shell * DoubleStack valve
* 6 port injection valve
* FWS in front of 6 port valve
* Gradient Pump
* Regeneration pump 		* Integration with Analyst Software
* Single Sample List
* Provides staggering of injections
* Multiplexes 2 separate LC systems into on MS 		* Does not support 21CFR11 compliance
* Requires pumps to be integrated with LEAP Shell 		No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-006
[5] 		Inline Sample Concentration

SPE Column regenerated during analytical extraction 		Analyst with ICC-CE * TrioVS
* Automated concentration and elution of sample on SPE column prior to separation on analytical column * No "Look Ahead"
* Can not prep samples ahead of analytical run 		No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-007
[6] 		Inline Sample Filtration

SPE Column regenerated during analytical extraction 		Analyst with ICC-CE * TrioVS
* Automated filtration of sample on cleanup column prior to separation on analytical column * No "Look Ahead"
* Can not prep samples ahead of analytical run 		No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-008
[7] 		Dual Channel In-line Sample Concentration

SPE Column regenerated during analytical extraction 		Cycle Composer outside of Analyst * TrioVS
* Dual Stream
* High throughput sample cleanup "Look Ahead" 		* Requires two matching sample lists No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-009
[8] 		Dual Channel in-line Sample Filtration

SPE Column regenerated during analytical extraction 		Cycle Composer outside of Analyst * TrioVS
* Dual Stream
* High throughput sample cleanup
* "Look Ahead" 		* Requires two matching sample lists No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-010
[9] 		Dual Channel in-line Sample Concentration

SPE Column regenerated during analytical extraction 		LEAP Shell * TrioVS
* High throughput sample cleanup "Look Ahead" No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-011
[10] 		Dual Channel in-line Sample Filtration

SPE Column regenerated during analytical extraction 		LEAP Shell * TrioVS
* High throughput sample cleanup "Look Ahead" No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-014
[11] 		Selectable HPLC

(max 2 Streams) 		Analyst Standard Cycles * Two Injection Valves
* MS Stream Selector 		* Different Analyst Methods inject into different LC Valves
* Uses Standard Analyst cycles 		* Requires Analyst control of the stream selector valve
* Max of 2 streams can be supported 		Yes


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-015
[12] 		Selectable HPLC

(max 4 Streams) 		Analyst with ICC-CE * Multiple Injection Valves (serial control)
* PAL 10 port Valve for Stream Selector 		* Different Analyst Methods inject into different LC Valves
* Stream selection to MS 		* PAL controls the stream selector valve
* Requires Custom Cycle 		Yes


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-016
[13] 		Column Selection

Method selects which HPLC column is in-line before injection 		Analyst with ICC-CE * CTC Column Selector
* Up to 5 columns 		* Automated switching between analytical columns within run * Requires Custom Cycles Yes

For other cost/time saving measures consider:

  • LEAP offers multiple choices of Valve Self Wash Stations to aid in cleaning the valve [14]
  • LEAP Shell Software and application for custom injections and scheduling [15]
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www.leaptec.com
www.leapwiki.com

Contact LEAP

For additional information about this technique please contact LEAP Technologies for detailed information

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