Summary of LC Multi Valve Applications
From LEAP
(Difference between revisions)
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!width="15"|GLP | !width="15"|GLP | ||
|- align=left | |- align=left | ||
- | | style="border:1px solid blue;"|'''M-014'''<br>[http://www.leapwiki.com/mediawiki/index.php?title= | + | | style="border:1px solid blue;"|'''M-014'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=Selectable_HPLC_Streams] |
| style="border:1px solid blue;"|'''Selectable HPLC'''<br><br>(max 2 Streams) | | style="border:1px solid blue;"|'''Selectable HPLC'''<br><br>(max 2 Streams) | ||
| style="border:1px solid blue;"|Analyst Standard Cycles | | style="border:1px solid blue;"|Analyst Standard Cycles | ||
| style="border:1px solid blue;"|* Two Injection Valves<br>* MS Stream Selector | | style="border:1px solid blue;"|* Two Injection Valves<br>* MS Stream Selector | ||
| style="border:1px solid blue;"|* Different Analyst Methods inject into different LC Valves <br>* Uses Standard Analyst cycles | | style="border:1px solid blue;"|* Different Analyst Methods inject into different LC Valves <br>* Uses Standard Analyst cycles | ||
- | | style="border:1px solid blue;"|* Requires Analyst control of the stream selector valve < | + | | style="border:1px solid blue;"|* Requires Analyst control of the stream selector valve <br>* Max of 2 streams can be supported |
+ | | style="border:1px solid blue;"|No | ||
+ | |} | ||
+ | <br> | ||
+ | {| cellpadding="6" style="border:1px solid darkgray;" | ||
+ | |- align=left | ||
+ | !width="20"|Code | ||
+ | !width="195"|Application | ||
+ | !width="85"|Control SW | ||
+ | !width="140"|Key Hardware | ||
+ | !width="205"|Key Benefits | ||
+ | !width="235"|Restrictions | ||
+ | !width="15"|GLP | ||
+ | |- align=left | ||
+ | | style="border:1px solid blue;"|'''M-015'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=Selectable_HPLC_Streams] | ||
+ | | style="border:1px solid blue;"|'''Selectable HPLC'''<br><br>(max 4 Streams) | ||
+ | | style="border:1px solid blue;"|Analyst with ICC-CE | ||
+ | | style="border:1px solid blue;"|* Multiple Injection Valves (serial control)<br>* PAL 10 port Valve for Stream Selector | ||
+ | | style="border:1px solid blue;"|* Different Analyst Methods inject into different LC Valves <br>* Stream selection to MS | ||
+ | | style="border:1px solid blue;"|* PAL controls the stream selector valve <br>* Requires Custom Cycle | ||
| style="border:1px solid blue;"|No | | style="border:1px solid blue;"|No | ||
|} | |} |
Revision as of 20:26, 11 May 2009
LC Multiple Valve Applications | |
Application Type | |
STANDARD AND SPECIAL | |
Application ID | |
Description | |
Multiple Valve Applications for LC |
Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
---|---|---|---|---|---|---|
M-001 [1] | Dual Channel Serial Injection Provides shorter cycle times by regenerating columns during next analytical run | Analyst with ICC-CE | * 6 port injection valve * 10 port Valve * Gradient Pump * Regeneration pump | * Saving of regeneration time(Back Cut) * Increase throughput at little cost * Control is all within Analyst * Compliance is not affected | * Can not do "Look Ahead" * Injections are not staggered * Peaks of interest must come of early * Columns may perform slightly differently on alternating samples | Yes |
Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
---|---|---|---|---|---|---|
M-002 [2] | Dual Channel Serial Injection with Front Cut Provides shorter cycle times by regenerating columns during next analytical run and diverts the solvent front to waste | Analyst with ICC-CE | * Trio VS * Gradient Pump * Regeneration pump | * Saving of regeneration time(Back Cut) * Increase throughput at little cost * Control is all within Analyst * Compliance is not affected * Avoids contaminating MS inlet with early eluting compounds and solvent | * Can not do "Look Ahead" * Injections are not staggered * Peaks of interest must come of early * Columns may perform slightly differently on alternating samples | Yes |
Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
---|---|---|---|---|---|---|
M-003 [3] | Dual Channel Parallel Injection Provides shorter cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition | Cycle Composer outside of Analyst | * DoubleStack valve *6 port injection valve * FWS in front of 6 port valve * Gradient Pump * Regeneration pump | * Saving of Front and Back Cut * Provides "Look Ahead" * Provides staggering of injections | * Requires matching sample lists in Cycle Composer and Analyst * Columns may perform slightly differently on alternating samples | No |
Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
---|---|---|---|---|---|---|
M-005 [4] | Dual Channel Parallel Injection Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition | LEAP Shell | * DoubleStack valve * 6 port injection valve * FWS in front of 6 port valve * Gradient Pump * Regeneration pump | * Integration with Analyst Software * Single Sample List * Provides staggering of injections * Multiplexes 2 separate LC systems into on MS | * Does not support 21CFR11 compliance * Requires pumps to be integrated with LEAP Shell | No |
Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
---|---|---|---|---|---|---|
M-006 [5] | Inline Sample Concentration SPE Column regenerated during analytical extraction | Analyst with ICC-CE | * TrioVS | * Automated concentration and elution of sample on SPE column prior to separation on analytical column | * No "Look Ahead" * Can not prep samples ahead of analytical run | No |
Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
---|---|---|---|---|---|---|
M-007 [6] | Inline Sample Filtration SPE Column regenerated during analytical extraction | Analyst with ICC-CE | * TrioVS | * Automated filtration of sample on cleanup column prior to separation on analytical column | * No "Look Ahead" * Can not prep samples ahead of analytical run | No |
Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
---|---|---|---|---|---|---|
M-008 [7] | Dual Channel In-line Sample Concentration SPE Column regenerated during analytical extraction | Cycle Composer outside of Analyst | * TrioVS | * Dual Stream * High throughput sample cleanup "Look Ahead" | * Requires two matching sample lists | No |
Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
---|---|---|---|---|---|---|
M-009 [8] | Dual Channel in-line Sample Filtration SPE Column regenerated during analytical extraction | Cycle Composer outside of Analyst | * TrioVS | * Dual Stream * High throughput sample cleanup * "Look Ahead" | * Requires two matching sample lists | No |
Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
---|---|---|---|---|---|---|
M-010 [9] | Dual Channel in-line Sample Concentration SPE Column regenerated during analytical extraction | LEAP Shell | * TrioVS | * High throughput sample cleanup "Look Ahead" | No |
Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
---|---|---|---|---|---|---|
M-011 [10] | Dual Channel in-line Sample Filtration SPE Column regenerated during analytical extraction | LEAP Shell | * TrioVS | * High throughput sample cleanup "Look Ahead" | No |
Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
---|---|---|---|---|---|---|
M-014 [11] | Selectable HPLC (max 2 Streams) | Analyst Standard Cycles | * Two Injection Valves * MS Stream Selector | * Different Analyst Methods inject into different LC Valves * Uses Standard Analyst cycles | * Requires Analyst control of the stream selector valve * Max of 2 streams can be supported | No |
Code | Application | Control SW | Key Hardware | Key Benefits | Restrictions | GLP |
---|---|---|---|---|---|---|
M-015 [12] | Selectable HPLC (max 4 Streams) | Analyst with ICC-CE | * Multiple Injection Valves (serial control) * PAL 10 port Valve for Stream Selector | * Different Analyst Methods inject into different LC Valves * Stream selection to MS | * PAL controls the stream selector valve * Requires Custom Cycle | No |
For other cost/time saving measures consider:
- LEAP offers multiple choices of Valve Self Wash Stations to aid in cleaning the valve [13]
- LEAP Shell Software and application for custom injections and scheduling [14]
Contact LEAP
For additional information about this technique please contact LEAP Technologies for detailed information