Summary of LC Multi Valve Applications

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| style="border:1px solid blue;"|'''M-005'''
 
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| style="border:1px solid blue;"|'''Dual Channel Parallel Injection'''<br><br>Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition
 
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| style="border:1px solid blue;"|LEAP Shell
 
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| style="border:1px solid blue;"|*DoubleStack valve<br>*6 port injection valve<br>*FWS in front of 6 port valve<br>* Gradient Pump<br>* Regeneration pump
 
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| style="border:1px solid blue;"|*Integration with Analyst Software<br>*Single Sample List<br> *Provides staggering of injections<br> *Multiplexes 2 separate LC systems into on MS
 
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| style="border:1px solid blue;"|* Does not support 21CFR11 compliance<br>*Requires pumps to be integrated with LEAP Shell
 
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| style="border:1px solid blue;"|No
 
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{| cellpadding="6" style="border:1px solid darkgray;"
 
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|- align=left
 
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!width="20"|Code
 
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!width="195"|Application
 
-
!width="85"|Control SW
 
-
!width="140"|Key Hardware
 
-
!width="205"|Key Benefits
 
-
!width="235"|Restrictions
 
-
!width="15"|GLP
 
-
|- align=left
 
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| style="border:1px solid blue;"|'''M-005'''
 
-
| style="border:1px solid blue;"|'''Dual Channel Parallel Injection'''<br><br>Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition
 
-
| style="border:1px solid blue;"|LEAP Shell
 
-
| style="border:1px solid blue;"|*DoubleStack valve<br>*6 port injection valve<br>*FWS in front of 6 port valve<br>* Gradient Pump<br>* Regeneration pump
 
-
| style="border:1px solid blue;"|*Integration with Analyst Software<br>*Single Sample List<br> *Provides staggering of injections<br> *Multiplexes 2 separate LC systems into on MS
 
-
| style="border:1px solid blue;"|* Does not support 21CFR11 compliance<br>*Requires pumps to be integrated with LEAP Shell
 
-
| style="border:1px solid blue;"|No
 
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|}
 
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<br>
 
-
{| cellpadding="6" style="border:1px solid darkgray;"
 
-
|- align=left
 
-
!width="20"|Code
 
-
!width="195"|Application
 
-
!width="85"|Control SW
 
-
!width="140"|Key Hardware
 
-
!width="205"|Key Benefits
 
-
!width="235"|Restrictions
 
-
!width="15"|GLP
 
-
|- align=left
 
-
| style="border:1px solid blue;"|'''M-005'''
 
-
| style="border:1px solid blue;"|'''Dual Channel Parallel Injection'''<br><br>Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition
 
-
| style="border:1px solid blue;"|LEAP Shell
 
-
| style="border:1px solid blue;"|*DoubleStack valve<br>*6 port injection valve<br>*FWS in front of 6 port valve<br>* Gradient Pump<br>* Regeneration pump
 
-
| style="border:1px solid blue;"|*Integration with Analyst Software<br>*Single Sample List<br> *Provides staggering of injections<br> *Multiplexes 2 separate LC systems into on MS
 
-
| style="border:1px solid blue;"|* Does not support 21CFR11 compliance<br>*Requires pumps to be integrated with LEAP Shell
 
-
| style="border:1px solid blue;"|No
 
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=== For other cost/time saving measures consider:===
=== For other cost/time saving measures consider:===

Revision as of 17:37, 11 May 2009

LC Multiple Valve Applications
Application Type
  STANDARD AND SPECIAL
Application ID
 
Description
  Multiple Valve Applications for LC


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-001 Dual Channel Serial Injection

Provides shorter cycle times by regenerating columns during next analytical run
Analyst with ICC-CE * 6 port injection valve
* 10 port Valve
* Gradient Pump
* Regeneration pump
* Saving of regeneration time(Back Cut)
* Increase throughput at little cost
* Control is all within Analyst
* Compliance is not affected
* Can not do "Look Ahead"
* Injections are not staggered
* Peaks of interest must come of early
* Columns may perform slightly differently on alternating samples
Yes
Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-002 Dual Channel Serial Injection with Front Cut

Provides shorter cycle times by regenerating columns during next analytical run and diverts the solvent front to waste
Analyst with ICC-CE * Trio VS
* Gradient Pump
* Regeneration pump
* Saving of regeneration time(Back Cut)
* Increase throughput at little cost
* Control is all within Analyst
* Compliance is not affected
* Avoids contaminating MS inlet with early eluting compounds and solvent
* Can not do "Look Ahead"
* Injections are not staggered
* Peaks of interest must come of early
* Columns may perform slightly differently on alternating samples
Yes


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-003 Dual Channel Parallel Injection

Provides shorter cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition
Cycle Composer outside of Analyst * DoubleStack valve
*6 port injection valve
*FWS in front of 6 port valve
* Gradient Pump
* Regeneration pump
* Saving of Front and Back Cut
* Provides "Look Ahead"
*Provides staggering of injections
* Requires matching sample lists in Cycle Composer and Analyst
* Columns may perform slightly differently on alternating samples
No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-005 Dual Channel Parallel Injection

Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition
LEAP Shell *DoubleStack valve
*6 port injection valve
*FWS in front of 6 port valve
* Gradient Pump
* Regeneration pump
*Integration with Analyst Software
*Single Sample List
*Provides staggering of injections
*Multiplexes 2 separate LC systems into on MS
* Does not support 21CFR11 compliance
*Requires pumps to be integrated with LEAP Shell
No



For other cost/time saving measures consider:

  • LEAP offers multiple choices of Valve Self Wash Stations to aid in cleaning the valve [1]
  • Dual Channel Serial Injection (M-001) using Analyst and ICC-CE [2]
  • Dual Channel Serial Injection with Front Cut (M-002) using Analyst and ICC-CE [3]
  • Dual Channel Parallel Injection (M-003) using Cycle Composer Software and Analyst [4]
  • “Look Ahead”, sample prep before injection (M-004) using LEAP Shell Software [5]
  • Dual Channel Parallel Injection (M-005) using LEAP Shell software [6]
  • LEAP Shell Software and application for custom injections and scheduling [7]

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For additional information about this technique please contact LEAP Technologies for detailed information

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