LC Multi-Valve Applications

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   |description = Multiple Valve Applications for LC
   |description = Multiple Valve Applications for LC
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{{logo}}
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[[Image:LEAP Logo.png|frame|[http://www.leaptec.com leaptec.com]<br />[http://www.leapwiki.com leapwiki.com]]]
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<br>
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'''Overview'''
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*[[Summary of LC Multi Valve Applications]]
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<br>
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----
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'''Specific Categories'''
'''Specific Categories'''
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*[[Selectable HPLC Streams]]
*[[Selectable HPLC Streams]]
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There are many techniques and applications that [http://www.leaptec.com/ LEAP Technologies] can help you with to increase sample throughput with automated injection [http://leapwiki.com/mediawiki/index.php?title=Category:HPLC HPLC] and [http://www.leapwiki.com/mediawiki/index.php?title=UPLC UPLC] systems. From [http://www.leapwiki.com/mediawiki/index.php?title=Category:Frontcut "Front Cuts"] to [http://www.leapwiki.com/mediawiki/index.php?title=Category:Heart_Cut "Heart Cuts"] to [http://www.leapwiki.com/mediawiki/index.php?title=Category:Backcut "Back Cuts"] to [http://www.leapwiki.com/mediawiki/index.php?title=Category:Multiplexing "Multiplexing"]. Typical applications are pre-column SPE, pre-column cleanup, sample desalting,parallel column [http://www.leapwiki.com/mediawiki/index.php?title=Category:Regeneration regeneration], etc. LEAP has the experience to solve your throughput needs. These are just a few of our offerings. We integrate multiple vendors HPLC systems and have a wide array of injection valves and selector valves to get you the best result. Many of these can be added to your existing systems to better utilize the hardware you already have with some additional [http://www.leapwiki.com/mediawiki/index.php?title=Valve_Switching_Modules valve switching modules] from [http://www.leaptec.com/ LEAP Technologies].
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<br>
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----
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{| cellpadding="6" style="border:1px solid darkgray;"
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|- align=left
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!width="20"|Code
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!width="195"|Application
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!width="85"|Control SW
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!width="140"|Key Hardware
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!width="205"|Key Benefits
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!width="235"|Restrictions
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!width="15"|GLP
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|- align=left
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| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=M-001_Dual_Channel_Serial_Injection_-_Analyst_with_ICC-CE M-001]'''
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| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=M-001_Dual_Channel_Serial_Injection_-_Analyst_with_ICC-CE Dual Channel Serial Injections]'''<br><br>Provides shorter cycle times by regenerating columns during next analytical run
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| style="border:1px solid blue;"|Analyst with ICC-CE
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| style="border:1px solid blue;"|* 6 port injection valve<BR>* 10 port Valve <br>* Gradient Pump<br>* Regeneration pump
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| style="border:1px solid blue;"|* Saving of regeneration time(Back Cut)<br>* Increase throughput at little cost<br> * Control is all within Analyst<br>* Compliance is not affected
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| style="border:1px solid blue;"|* Can not do "Look Ahead"<br>* Injections are not staggered<br>* Peaks of interest must come of early<br>* Columns may perform slightly differently on alternating samples
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| style="border:1px solid blue;"|Yes
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|}
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{| cellpadding="6" style="border:1px solid darkgray;"
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|- align=left
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!width="20"|Code
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!width="195"|Application
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!width="85"|Control SW
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!width="140"|Key Hardware
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!width="205"|Key Benefits
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!width="235"|Restrictions
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!width="15"|GLP
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|- align=left
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| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=M-002_Dual_Channel_Serial_Injection_with_front_cut_-_Analyst_with_ICC-CE M-002]'''
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| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=M-002_Dual_Channel_Serial_Injection_with_front_cut_-_Analyst_with_ICC-CE Dual Channel Serial Injection with Front Cut]'''<br><br>Provides shorter cycle times by regenerating columns during next analytical run and diverts the solvent front to waste
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| style="border:1px solid blue;"|Analyst with ICC-CE
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| style="border:1px solid blue;"|* Trio VS<br>* Gradient Pump<br>* Regeneration pump
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| style="border:1px solid blue;"|* Saving of regeneration time(Back Cut)<br>* Increase throughput at little cost<br> * Control is all within Analyst<br>* Compliance is not affected <br>* Avoids contaminating MS inlet with early eluting compounds and solvent
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| style="border:1px solid blue;"|* Can not do "Look Ahead"<br>* Injections are not staggered<br>* Peaks of interest must come of early<br>* Columns may perform slightly differently on alternating samples
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| style="border:1px solid blue;"|Yes
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|}
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{| cellpadding="6" style="border:1px solid darkgray;"
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|- align=left
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!width="20"|Code
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!width="195"|Application
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!width="85"|Control SW
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!width="140"|Key Hardware
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!width="205"|Key Benefits
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!width="235"|Restrictions
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!width="15"|GLP
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|- align=left
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| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=M-003_Dual_Channel_Parallel_Injection_-_Cycle_Composer M-003]'''
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| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=M-003_Dual_Channel_Parallel_Injection_-_Cycle_Composer Dual Channel Parallel Injection]'''<br><br>Provides shorter cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition
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| style="border:1px solid blue;"|Cycle Composer outside of Analyst
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| style="border:1px solid blue;"|* DoubleStack valve<br>* 6 port injection valve<br>* FWS in front of 6 port valve<br>* Gradient Pump<br>* Regeneration pump
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| style="border:1px solid blue;"|* Saving of Front and Back Cut<br>* Provides "Look Ahead"<br> * Provides staggering of injections
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| style="border:1px solid blue;"|* Requires matching sample lists in Cycle Composer and Analyst<br>* Columns may perform slightly differently on alternating samples
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| style="border:1px solid blue;"|No
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|}
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<br>
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{| cellpadding="6" style="border:1px solid darkgray;"
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|- align=left
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!width="20"|Code
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!width="195"|Application
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!width="85"|Control SW
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!width="140"|Key Hardware
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!width="205"|Key Benefits
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!width="235"|Restrictions
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!width="15"|GLP
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|- align=left
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| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=Category:LEAP_Shell M-004]'''
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| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=Category:LEAP_Shell Analyst with "Look Ahead" with LEAP Shell]'''<br><br>Control of the Sample List is through LEAP Shell
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| style="border:1px solid blue;"|LEAP Shell
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| style="border:1px solid blue;"|* Standard PAL <br>* Pumps are supported within Analyst
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| style="border:1px solid blue;"|* "Look Ahead" <br> * Can import custom columns<br> * Freedom to create and use custom Cycles
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| style="border:1px solid blue;"|* Does not support 21CFR11 compliance<br>
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| style="border:1px solid blue;"|No
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|}
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<br>
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{| cellpadding="6" style="border:1px solid darkgray;"
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|- align=left
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!width="20"|Code
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!width="195"|Application
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!width="85"|Control SW
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!width="140"|Key Hardware
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!width="205"|Key Benefits
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!width="235"|Restrictions
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!width="15"|GLP
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|- align=left
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| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=M-005_Dual_Channel_Parallel_Injection_-_LEAP_Shell_%22(M-Fab)%22 M-005]'''
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| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=M-005_Dual_Channel_Parallel_Injection_-_LEAP_Shell_%22(M-Fab)%22 Dual Channel Parallel Injection]'''<br><br>Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition
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| style="border:1px solid blue;"|LEAP Shell
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| style="border:1px solid blue;"|* DoubleStack valve<br>* 6 port injection valve<br>* FWS in front of 6 port valve<br>* Gradient Pump<br>* Regeneration pump
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| style="border:1px solid blue;"|* Integration with Analyst Software<br>* Single Sample List<br> * Provides staggering of injections<br> * Multiplexes 2 separate LC systems into on MS
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| style="border:1px solid blue;"|* Does not support 21CFR11 compliance<br>* Requires pumps to be integrated with LEAP Shell
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| style="border:1px solid blue;"|No
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|}
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<br>
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{| cellpadding="6" style="border:1px solid darkgray;"
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|- align=left
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!width="20"|Code
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!width="195"|Application
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!width="85"|Control SW
 +
!width="140"|Key Hardware
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!width="205"|Key Benefits
 +
!width="235"|Restrictions
 +
!width="15"|GLP
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|- align=left
 +
| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=M-006_%26_M-007_In-Line_Sample_Concentration_or_Filtration M-006]'''
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| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=M-006_%26_M-007_In-Line_Sample_Concentration_or_Filtration Inline Sample Concentration]'''<br><br>SPE Column regenerated during analytical extraction
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| style="border:1px solid blue;"|Analyst with ICC-CE
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| style="border:1px solid blue;"|* TrioVS<br>
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| style="border:1px solid blue;"|* Automated concentration and elution of sample on SPE column prior to separation on analytical column
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| style="border:1px solid blue;"|* No "Look Ahead" <br>* Can not prep samples ahead of analytical run
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| style="border:1px solid blue;"|No
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|}
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<br>
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{| cellpadding="6" style="border:1px solid darkgray;"
 +
|- align=left
 +
!width="20"|Code
 +
!width="195"|Application
 +
!width="85"|Control SW
 +
!width="140"|Key Hardware
 +
!width="205"|Key Benefits
 +
!width="235"|Restrictions
 +
!width="15"|GLP
 +
|- align=left
 +
| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=M-006_%26_M-007_In-Line_Sample_Concentration_or_Filtration M-007]'''
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| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=M-006_%26_M-007_In-Line_Sample_Concentration_or_Filtration Inline Sample Filtration]'''<br><br>SPE Column regenerated during analytical extraction
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| style="border:1px solid blue;"|Analyst with ICC-CE
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| style="border:1px solid blue;"|* TrioVS<br>
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| style="border:1px solid blue;"|* Automated filtration of sample on cleanup column prior to separation on analytical column
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| style="border:1px solid blue;"|* No "Look Ahead" <br>* Can not prep samples ahead of analytical run
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| style="border:1px solid blue;"|No
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|}
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<br>
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{| cellpadding="6" style="border:1px solid darkgray;"
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|- align=left
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!width="20"|Code
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!width="195"|Application
 +
!width="85"|Control SW
 +
!width="140"|Key Hardware
 +
!width="205"|Key Benefits
 +
!width="235"|Restrictions
 +
!width="15"|GLP
 +
|- align=left
 +
| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=M-008_%26_M-009_Dual_Channel_In-Line_Sample_Concentration_or_Filtration M-008]'''
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| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=M-008_%26_M-009_Dual_Channel_In-Line_Sample_Concentration_or_Filtration M-008 Dual Channel In-line Sample Concentration]'''<br><br>SPE Column regenerated during analytical extraction
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| style="border:1px solid blue;"|Cycle Composer outside of Analyst
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| style="border:1px solid blue;"|* TrioVS<br>
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| style="border:1px solid blue;"|* Dual Stream <br>* High throughput sample cleanup "Look Ahead"
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| style="border:1px solid blue;"|* Requires two matching sample lists
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| style="border:1px solid blue;"|No
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|}
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<br>
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{| cellpadding="6" style="border:1px solid darkgray;"
 +
|- align=left
 +
!width="20"|Code
 +
!width="195"|Application
 +
!width="85"|Control SW
 +
!width="140"|Key Hardware
 +
!width="205"|Key Benefits
 +
!width="235"|Restrictions
 +
!width="15"|GLP
 +
|- align=left
 +
| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=M-008_%26_M-009_Dual_Channel_In-Line_Sample_Concentration_or_Filtration M-009]'''
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| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=M-008_%26_M-009_Dual_Channel_In-Line_Sample_Concentration_or_Filtration Dual Channel in-line Sample Filtration]'''<br><br>SPE Column regenerated during analytical extraction
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| style="border:1px solid blue;"|Cycle Composer outside of Analyst
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| style="border:1px solid blue;"|* TrioVS<br>
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| style="border:1px solid blue;"|* Dual Stream <br>* High throughput sample cleanup <br>* "Look Ahead"
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| style="border:1px solid blue;"|* Requires two matching sample lists
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| style="border:1px solid blue;"|No
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|}
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<br>
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{| cellpadding="6" style="border:1px solid darkgray;"
 +
|- align=left
 +
!width="20"|Code
 +
!width="195"|Application
 +
!width="85"|Control SW
 +
!width="140"|Key Hardware
 +
!width="205"|Key Benefits
 +
!width="235"|Restrictions
 +
!width="15"|GLP
 +
|- align=left
 +
| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=M-010_%26_M011_Dual_Channel_In-Line_Sample_Concentration_or_Filtration_-_LEAP_Shell M-010]'''
 +
| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=M-010_%26_M011_Dual_Channel_In-Line_Sample_Concentration_or_Filtration_-_LEAP_Shell Dual Channel in-line Sample Concentration]'''<br><br>SPE Column regenerated during analytical extraction
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| style="border:1px solid blue;"|LEAP Shell
 +
| style="border:1px solid blue;"|* TrioVS<br>
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| style="border:1px solid blue;"|* High throughput sample cleanup "Look Ahead"
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| style="border:1px solid blue;"|
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| style="border:1px solid blue;"|No
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|}
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<br>
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{| cellpadding="6" style="border:1px solid darkgray;"
 +
|- align=left
 +
!width="20"|Code
 +
!width="195"|Application
 +
!width="85"|Control SW
 +
!width="140"|Key Hardware
 +
!width="205"|Key Benefits
 +
!width="235"|Restrictions
 +
!width="15"|GLP
 +
|- align=left
 +
| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=M-010_%26_M011_Dual_Channel_In-Line_Sample_Concentration_or_Filtration_-_LEAP_Shell M-011]'''
 +
| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=M-010_%26_M011_Dual_Channel_In-Line_Sample_Concentration_or_Filtration_-_LEAP_Shell Dual Channel in-line Sample Filtration]'''<br><br>SPE Column regenerated during analytical extraction
 +
| style="border:1px solid blue;"|LEAP Shell
 +
| style="border:1px solid blue;"|* TrioVS<br>
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| style="border:1px solid blue;"|* High throughput sample cleanup "Look Ahead"
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| style="border:1px solid blue;"|
 +
| style="border:1px solid blue;"|No
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|}
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<br>
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{| cellpadding="6" style="border:1px solid darkgray;"
 +
|- align=left
 +
!width="20"|Code
 +
!width="195"|Application
 +
!width="85"|Control SW
 +
!width="140"|Key Hardware
 +
!width="205"|Key Benefits
 +
!width="235"|Restrictions
 +
!width="15"|GLP
 +
|- align=left
 +
| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=Selectable_HPLC_Streams M-014]'''
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| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=Selectable_HPLC_Streams Selectable HPLC]'''<br><br>(max 2 Streams)
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| style="border:1px solid blue;"|Analyst Standard Cycles
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| style="border:1px solid blue;"|* Two Injection Valves<br>* MS Stream Selector
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| style="border:1px solid blue;"|* Different Analyst Methods inject into different LC Valves <br>* Uses Standard Analyst cycles
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| style="border:1px solid blue;"|* Requires Analyst control of the stream selector valve <br>* Max of 2 streams can be supported
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| style="border:1px solid blue;"|Yes
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|}
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<br>
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{| cellpadding="6" style="border:1px solid darkgray;"
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|- align=left
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!width="20"|Code
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!width="195"|Application
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!width="85"|Control SW
 +
!width="140"|Key Hardware
 +
!width="205"|Key Benefits
 +
!width="235"|Restrictions
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!width="15"|GLP
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|- align=left
 +
| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=Selectable_HPLC_Streams M-015]'''
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| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=Selectable_HPLC_Streams Selectable HPLC]'''<br><br>(max 4 Streams)
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| style="border:1px solid blue;"|Analyst with ICC-CE
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| style="border:1px solid blue;"|* Multiple Injection Valves (serial control)<br>* PAL 10 port Valve for Stream Selector
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| style="border:1px solid blue;"|* Different Analyst Methods inject into different LC Valves <br>* Stream selection to MS
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| style="border:1px solid blue;"|* PAL controls the stream selector valve <br>* Requires Custom Cycle
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| style="border:1px solid blue;"|Yes
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|}
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<br>
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{| cellpadding="6" style="border:1px solid darkgray;"
 +
|- align=left
 +
!width="20"|Code
 +
!width="195"|Application
 +
!width="85"|Control SW
 +
!width="140"|Key Hardware
 +
!width="205"|Key Benefits
 +
!width="235"|Restrictions
 +
!width="15"|GLP
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|- align=left
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| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=Column_Selection M-016]'''
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| style="border:1px solid blue;"|'''[http://www.leapwiki.com/mediawiki/index.php?title=Column_Selection Column Selection]'''<br><br> Method selects which HPLC column is in-line before injection
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| style="border:1px solid blue;"|Analyst with ICC-CE
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| style="border:1px solid blue;"|* CTC Column Selector <br>* Up to 5 columns
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| style="border:1px solid blue;"|* Automated switching between analytical columns within run
 +
| style="border:1px solid blue;"|* Requires Custom Cycles
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| style="border:1px solid blue;"|Yes
 +
|}
 +
<br>
 +
''' Why invest in Multi-Valve Applications? '''
 +
* More through-put
 +
* Faster gradient
 +
* Pre-separation, SPE with better detection
 +
* Keep detector system clean
 +
* Convenience
 +
* Controlled from one software
 +
* Support
 +
<br>
 +
''' Videos '''
 +
<br>
 +
[[Image:Movie Icon.png|40px]]
 +
[http://www.youtube.com/user/LEAPTechnologies#g/u LEAP's CTC PAL Videos on YouTube]
 +
<br>
 +
----
 +
''' Print '''
 +
<br>
 +
[[image:Download Icon.png|40px]] [[:Media:Summary_LC_Multi_Valve_Applications.pdf‎ | PDF of Summary LC Multi Valve_Applications page formatted for printing]]
 +
‎<br>
 +
 +
----
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{{logo}}
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[http://www.leaptec.com/ LEAP Technologies] provides fully automated sample processing workstation instrumentation solutions based on the LEAP CTC [http://leapwiki.com/mediawiki/index.php?title=Category:PAL PAL] X, Y, Z syringe only autosampler robot. This extremely flexible, precise, and adaptable liquid handling robotic platform is available in a variety of lengths and options depending on the requirements of your sample preparation and injections for your UHPLC, LC or GC chromatography. LEAP also offers process control systems and stand alone workstations. LEAP is an open, neutral resource for technical support of existing PAL. Keep your PAL in peak working order LEAP offers full [http://www.leapwiki.com/mediawiki/index.php?title=Category:Service support and service] for the PAL platform with over 11 years of history with the PAL. LEAP can also write custom macros, [http://www.leapwiki.com/mediawiki/index.php?title=Category:Cycles cycles], and scheduling [http://www.leapwiki.com/mediawiki/index.php?title=Category:Software software] for your specific applications. We're proud that LEAP is known as a productivity improver for laboratories including government labs in agencies such as FDA, USDA, EPA, FBI, Armed Forces, Homeland Security and others function more efficiently. Robotic sample prep equipment works well in government labs and challenges lab technicians to keep feeding those more samples. Analytical equipment such as chromatographs and mass spectrometers are expensive devices and also expensive to maintain. LEAP can help to keep them running and analyze samples around the clock. LEAP has most of its laboratory automation robots under [http://leapwiki.com/mediawiki/index.php?title=Category:GSA GSA]contract and is eager to service and maintain everything it sells to keep your expensive lab equipment running around the clock. CTC Analytics Combi PAL and HTS PAL for Front-End Automation for LC and GC applications. LEAP offers customized on-site training. LEAP Is continuing to develop FAQ, Solutions, Tips & Techniques,a Learning Center with the LEAP Wiki for the benefit of all PAL Platform Robotic users. We will continue exceeding customer expectations for quality, cost effective and efficient results using the most current technology and expertise in our industry. Our aim is to be the ultimate knowledge base on everything related to the PAL. LEAP is known as the autosamplerguys being in business over twenty years. LEAP has extensive multi-vendor experience with integrating the PAL. HTX, HTS, HTC, HTX-xt, HTS-xt, HTC-xt, LC-Mini, Combi PAL,COMBI-xt PAL, and GC PAL models. We have the Quality, Training, Parts availability, Infrastructure, and Experience.LEAP is sometimes referred to as an Application Automation House who is continually adding new products and solutions to its Lab Automation line. As we do so we change the content of this web site so please check back.<br>Please contact LEAP Technologies on how we can help you get maximized throughput with flexible pipetting automation solutions whether it is our standard applications or customized to your needs. The Combi-xt PAL autosampler is able to perform liquid and headspace analysis. Headspace options include Solid Phase Micro-extraction (SPME) and ITEX-2 as alternative to purge and trap. The HTS-xt PAL autosampler dramatically increases sample throughput by offering automated sample prep, Peltier cooled and heated sample storage using the cooled stack, Peltier cooled and heated sample storage using the cooled stack and low carryover due to the self-cleaning DLW (Dynamic Load and Wash) module and L-Mark syringes, peltier cooled valves and columns.  LEAP provides automation that fits your needs and reduces errors, increases sample capacity, increases efficiency, reduces cost by supplying long term productivity improvements with user friendly software and flexible hardware. LEAP performs just in time or on time sample prep and inject. LEAP offers full support of integrated and non-integrated PAL software with both sales and support for Cruise Control, Cycle Composer and Cycle Composer Macro Editor, Agilent ChemStation CTC Control, Mass Hunter and EZChrom CTC integration, Xcalibur, Waters Masslynx or Analyst CTC Control software, Thermo (Finnegan) XCalibur, LEAP Shell, and Chronos software. The PAL is more than just an autosampler, it is a high-quality and efficient laboratory robot platform that can be customized by LEAP Technologies to meet your specific needs.
 +
 +
=== Contact LEAP ===
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'''Keywords:''' Dual Channel, Single channel, Multiplexing, Serial Injection, shorter cycle times, regeneration of columns, PAL, 10 port valve, gradient pump, regeneration pump, 6 port injection valve,  saving, back cut, increase throughput, compliance, Look Ahead, staggered injections,  Peaks of interest early, columns, alternating samples, front cut, divert to waste, solvent, TRIO VS, saving of regeneration back cut, parallel injections,  staggering of injections, minimum cycle times, acquisition time, Flux pumps, Nano pump, Multiplexes, 2 separate LC systems into one Mass Spec, 21CFR11 compliance,  In-line sample concentration, SPE Column regenerated during analytical extraction, prep samples ahead of analytical run, In line sample filtration, In-line concentration, Dual Stream, sample cleanup, column regeneration, concentration,  Analyst Cycles, Stream Selector valve, PAL control, custom cycles, macros, CTC Column selector, Column selection, 4 streams, selectable HPLC, 2 streams, 4 streams, Analyst Software, ICC-CE software,LEAP Shell software,cycle composer software
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[[Category:LC Multi Valve Applications]]

Current revision

LC Multiple Valve Applications
Application Type
  STANDARD AND SPECIAL
Application ID
 
Description
  Multiple Valve Applications for LC
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Specific Categories

There are many techniques and applications that LEAP Technologies can help you with to increase sample throughput with automated injection HPLC and UPLC systems. From "Front Cuts" to "Heart Cuts" to "Back Cuts" to "Multiplexing". Typical applications are pre-column SPE, pre-column cleanup, sample desalting,parallel column regeneration, etc. LEAP has the experience to solve your throughput needs. These are just a few of our offerings. We integrate multiple vendors HPLC systems and have a wide array of injection valves and selector valves to get you the best result. Many of these can be added to your existing systems to better utilize the hardware you already have with some additional valve switching modules from LEAP Technologies.

Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-001 Dual Channel Serial Injections

Provides shorter cycle times by regenerating columns during next analytical run 		Analyst with ICC-CE * 6 port injection valve
* 10 port Valve
* Gradient Pump
* Regeneration pump 		* Saving of regeneration time(Back Cut)
* Increase throughput at little cost
* Control is all within Analyst
* Compliance is not affected 		* Can not do "Look Ahead"
* Injections are not staggered
* Peaks of interest must come of early
* Columns may perform slightly differently on alternating samples 		Yes
Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-002 Dual Channel Serial Injection with Front Cut

Provides shorter cycle times by regenerating columns during next analytical run and diverts the solvent front to waste 		Analyst with ICC-CE * Trio VS
* Gradient Pump
* Regeneration pump 		* Saving of regeneration time(Back Cut)
* Increase throughput at little cost
* Control is all within Analyst
* Compliance is not affected
* Avoids contaminating MS inlet with early eluting compounds and solvent 		* Can not do "Look Ahead"
* Injections are not staggered
* Peaks of interest must come of early
* Columns may perform slightly differently on alternating samples 		Yes


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-003 Dual Channel Parallel Injection

Provides shorter cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition 		Cycle Composer outside of Analyst * DoubleStack valve
* 6 port injection valve
* FWS in front of 6 port valve
* Gradient Pump
* Regeneration pump 		* Saving of Front and Back Cut
* Provides "Look Ahead"
* Provides staggering of injections 		* Requires matching sample lists in Cycle Composer and Analyst
* Columns may perform slightly differently on alternating samples 		No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-004 Analyst with "Look Ahead" with LEAP Shell

Control of the Sample List is through LEAP Shell 		LEAP Shell * Standard PAL
* Pumps are supported within Analyst 		* "Look Ahead"
* Can import custom columns
* Freedom to create and use custom Cycles 		* Does not support 21CFR11 compliance
No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-005 Dual Channel Parallel Injection

Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition 		LEAP Shell * DoubleStack valve
* 6 port injection valve
* FWS in front of 6 port valve
* Gradient Pump
* Regeneration pump 		* Integration with Analyst Software
* Single Sample List
* Provides staggering of injections
* Multiplexes 2 separate LC systems into on MS 		* Does not support 21CFR11 compliance
* Requires pumps to be integrated with LEAP Shell 		No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-006 Inline Sample Concentration

SPE Column regenerated during analytical extraction 		Analyst with ICC-CE * TrioVS
* Automated concentration and elution of sample on SPE column prior to separation on analytical column * No "Look Ahead"
* Can not prep samples ahead of analytical run 		No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-007 Inline Sample Filtration

SPE Column regenerated during analytical extraction 		Analyst with ICC-CE * TrioVS
* Automated filtration of sample on cleanup column prior to separation on analytical column * No "Look Ahead"
* Can not prep samples ahead of analytical run 		No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-008 M-008 Dual Channel In-line Sample Concentration

SPE Column regenerated during analytical extraction 		Cycle Composer outside of Analyst * TrioVS
* Dual Stream
* High throughput sample cleanup "Look Ahead" 		* Requires two matching sample lists No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-009 Dual Channel in-line Sample Filtration

SPE Column regenerated during analytical extraction 		Cycle Composer outside of Analyst * TrioVS
* Dual Stream
* High throughput sample cleanup
* "Look Ahead" 		* Requires two matching sample lists No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-010 Dual Channel in-line Sample Concentration

SPE Column regenerated during analytical extraction 		LEAP Shell * TrioVS
* High throughput sample cleanup "Look Ahead" No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-011 Dual Channel in-line Sample Filtration

SPE Column regenerated during analytical extraction 		LEAP Shell * TrioVS
* High throughput sample cleanup "Look Ahead" No


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-014 Selectable HPLC

(max 2 Streams) 		Analyst Standard Cycles * Two Injection Valves
* MS Stream Selector 		* Different Analyst Methods inject into different LC Valves
* Uses Standard Analyst cycles 		* Requires Analyst control of the stream selector valve
* Max of 2 streams can be supported 		Yes


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-015 Selectable HPLC

(max 4 Streams) 		Analyst with ICC-CE * Multiple Injection Valves (serial control)
* PAL 10 port Valve for Stream Selector 		* Different Analyst Methods inject into different LC Valves
* Stream selection to MS 		* PAL controls the stream selector valve
* Requires Custom Cycle 		Yes


Code Application Control SW Key Hardware Key Benefits Restrictions GLP
M-016 Column Selection

Method selects which HPLC column is in-line before injection 		Analyst with ICC-CE * CTC Column Selector
* Up to 5 columns 		* Automated switching between analytical columns within run * Requires Custom Cycles Yes


Why invest in Multi-Valve Applications?

  • More through-put
  • Faster gradient
  • Pre-separation, SPE with better detection
  • Keep detector system clean
  • Convenience
  • Controlled from one software
  • Support


Videos
LEAP's CTC PAL Videos on YouTube

Print
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LEAP Technologies provides fully automated sample processing workstation instrumentation solutions based on the LEAP CTC PAL X, Y, Z syringe only autosampler robot. This extremely flexible, precise, and adaptable liquid handling robotic platform is available in a variety of lengths and options depending on the requirements of your sample preparation and injections for your UHPLC, LC or GC chromatography. LEAP also offers process control systems and stand alone workstations. LEAP is an open, neutral resource for technical support of existing PAL. Keep your PAL in peak working order LEAP offers full support and service for the PAL platform with over 11 years of history with the PAL. LEAP can also write custom macros, cycles, and scheduling software for your specific applications. We're proud that LEAP is known as a productivity improver for laboratories including government labs in agencies such as FDA, USDA, EPA, FBI, Armed Forces, Homeland Security and others function more efficiently. Robotic sample prep equipment works well in government labs and challenges lab technicians to keep feeding those more samples. Analytical equipment such as chromatographs and mass spectrometers are expensive devices and also expensive to maintain. LEAP can help to keep them running and analyze samples around the clock. LEAP has most of its laboratory automation robots under GSAcontract and is eager to service and maintain everything it sells to keep your expensive lab equipment running around the clock. CTC Analytics Combi PAL and HTS PAL for Front-End Automation for LC and GC applications. LEAP offers customized on-site training. LEAP Is continuing to develop FAQ, Solutions, Tips & Techniques,a Learning Center with the LEAP Wiki for the benefit of all PAL Platform Robotic users. We will continue exceeding customer expectations for quality, cost effective and efficient results using the most current technology and expertise in our industry. Our aim is to be the ultimate knowledge base on everything related to the PAL. LEAP is known as the autosamplerguys being in business over twenty years. LEAP has extensive multi-vendor experience with integrating the PAL. HTX, HTS, HTC, HTX-xt, HTS-xt, HTC-xt, LC-Mini, Combi PAL,COMBI-xt PAL, and GC PAL models. We have the Quality, Training, Parts availability, Infrastructure, and Experience.LEAP is sometimes referred to as an Application Automation House who is continually adding new products and solutions to its Lab Automation line. As we do so we change the content of this web site so please check back.
Please contact LEAP Technologies on how we can help you get maximized throughput with flexible pipetting automation solutions whether it is our standard applications or customized to your needs. The Combi-xt PAL autosampler is able to perform liquid and headspace analysis. Headspace options include Solid Phase Micro-extraction (SPME) and ITEX-2 as alternative to purge and trap. The HTS-xt PAL autosampler dramatically increases sample throughput by offering automated sample prep, Peltier cooled and heated sample storage using the cooled stack, Peltier cooled and heated sample storage using the cooled stack and low carryover due to the self-cleaning DLW (Dynamic Load and Wash) module and L-Mark syringes, peltier cooled valves and columns. LEAP provides automation that fits your needs and reduces errors, increases sample capacity, increases efficiency, reduces cost by supplying long term productivity improvements with user friendly software and flexible hardware. LEAP performs just in time or on time sample prep and inject. LEAP offers full support of integrated and non-integrated PAL software with both sales and support for Cruise Control, Cycle Composer and Cycle Composer Macro Editor, Agilent ChemStation CTC Control, Mass Hunter and EZChrom CTC integration, Xcalibur, Waters Masslynx or Analyst CTC Control software, Thermo (Finnegan) XCalibur, LEAP Shell, and Chronos software. The PAL is more than just an autosampler, it is a high-quality and efficient laboratory robot platform that can be customized by LEAP Technologies to meet your specific needs.

Contact LEAP

Contact LEAP

For additional information about LEAP and the PAL Platform, please contact LEAP Technologies.


The information and references contained in this web site are believed to be accurate and the most current information available.



Keywords: Dual Channel, Single channel, Multiplexing, Serial Injection, shorter cycle times, regeneration of columns, PAL, 10 port valve, gradient pump, regeneration pump, 6 port injection valve, saving, back cut, increase throughput, compliance, Look Ahead, staggered injections, Peaks of interest early, columns, alternating samples, front cut, divert to waste, solvent, TRIO VS, saving of regeneration back cut, parallel injections, staggering of injections, minimum cycle times, acquisition time, Flux pumps, Nano pump, Multiplexes, 2 separate LC systems into one Mass Spec, 21CFR11 compliance, In-line sample concentration, SPE Column regenerated during analytical extraction, prep samples ahead of analytical run, In line sample filtration, In-line concentration, Dual Stream, sample cleanup, column regeneration, concentration, Analyst Cycles, Stream Selector valve, PAL control, custom cycles, macros, CTC Column selector, Column selection, 4 streams, selectable HPLC, 2 streams, 4 streams, Analyst Software, ICC-CE software,LEAP Shell software,cycle composer software

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