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{{LSApp
  |name        = LC Multiple Valve Applications
  |image       = valves.png
  |type        = '''STANDARD AND SPECIAL'''
  |id          = 
  |description = Multiple Valve Applications for LC
}}



{| cellpadding="6" style="border:1px solid darkgray;"
|- align=left
!width="20"|Code
!width="195"|Application
!width="85"|Control SW
!width="140"|Key Hardware
!width="205"|Key Benefits
!width="235"|Restrictions
!width="15"|GLP 
|- align=left
| style="border:1px solid blue;"|'''M-001'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=M-001_Dual_Channel_Serial_Injection_-_Analyst_with_ICC-CE]
| style="border:1px solid blue;"|'''Dual Channel Serial Injection'''<br><br>Provides shorter cycle times by regenerating columns during next analytical run
| style="border:1px solid blue;"|Analyst with ICC-CE 
| style="border:1px solid blue;"|* 6 port injection valve<BR>* 10 port Valve <br>* Gradient Pump<br>* Regeneration pump
| style="border:1px solid blue;"|* Saving of regeneration time(Back Cut)<br>* Increase throughput at little cost<br> * Control is all within Analyst<br>* Compliance is not affected
| style="border:1px solid blue;"|* Can not do "Look Ahead"<br>* Injections are not staggered<br>* Peaks of interest must come of early<br>* Columns may perform slightly differently on alternating samples
| style="border:1px solid blue;"|Yes
|}

{| cellpadding="6" style="border:1px solid darkgray;"
|- align=left
!width="20"|Code
!width="195"|Application
!width="85"|Control SW
!width="140"|Key Hardware
!width="205"|Key Benefits
!width="235"|Restrictions
!width="15"|GLP 
|- align=left
| style="border:1px solid blue;"|'''M-002'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=M-002_Dual_Channel_Serial_Injection_with_front_cut_-_Analyst_with_ICC-CE]
| style="border:1px solid blue;"|'''Dual Channel Serial Injection with Front Cut'''<br><br>Provides shorter cycle times by regenerating columns during next analytical run and diverts the solvent front to waste
| style="border:1px solid blue;"|Analyst with ICC-CE 
| style="border:1px solid blue;"|* Trio VS<br>* Gradient Pump<br>* Regeneration pump
| style="border:1px solid blue;"|* Saving of regeneration time(Back Cut)<br>* Increase throughput at little cost<br> * Control is all within Analyst<br>* Compliance is not affected <br>* Avoids contaminating MS inlet with early eluting compounds and solvent
| style="border:1px solid blue;"|* Can not do "Look Ahead"<br>* Injections are not staggered<br>* Peaks of interest must come of early<br>* Columns may perform slightly differently on alternating samples
| style="border:1px solid blue;"|Yes
|}


{| cellpadding="6" style="border:1px solid darkgray;"
|- align=left
!width="20"|Code
!width="195"|Application
!width="85"|Control SW
!width="140"|Key Hardware
!width="205"|Key Benefits
!width="235"|Restrictions
!width="15"|GLP 
|- align=left
| style="border:1px solid blue;"|'''M-003'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=M-003_Dual_Channel_Parallel_Injection_-_Cycle_Composer]
| style="border:1px solid blue;"|'''Dual Channel Parallel Injection'''<br><br>Provides shorter cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition
| style="border:1px solid blue;"|Cycle Composer outside of Analyst
| style="border:1px solid blue;"|* DoubleStack valve<br>* 6 port injection valve<br>* FWS in front of 6 port valve<br>* Gradient Pump<br>* Regeneration pump
| style="border:1px solid blue;"|* Saving of Front and Back Cut<br>* Provides "Look Ahead"<br> * Provides staggering of injections
| style="border:1px solid blue;"|* Requires matching sample lists in Cycle Composer and Analyst<br>* Columns may perform slightly differently on alternating samples
| style="border:1px solid blue;"|No
|}
<br>
{| cellpadding="6" style="border:1px solid darkgray;"
|- align=left
!width="20"|Code
!width="195"|Application
!width="85"|Control SW
!width="140"|Key Hardware
!width="205"|Key Benefits
!width="235"|Restrictions
!width="15"|GLP 
|- align=left
| style="border:1px solid blue;"|'''M-004'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=Category:LEAP_Shell]
| style="border:1px solid blue;"|'''Analyst with "Look Ahead" with LEAP Shell'''<br><br>Control of the Sample List is through LEAP Shell
| style="border:1px solid blue;"|LEAP Shell
| style="border:1px solid blue;"|* Standard PAL <br>* Pumps are supported within Analyst
| style="border:1px solid blue;"|* "Look Ahead" <br> * Can import custom columns<br> * Freedom to create and use custom Cycles
| style="border:1px solid blue;"|* Does not support 21CFR11 compliance<br>
| style="border:1px solid blue;"|No
|}
<br>
{| cellpadding="6" style="border:1px solid darkgray;"
|- align=left
!width="20"|Code
!width="195"|Application
!width="85"|Control SW
!width="140"|Key Hardware
!width="205"|Key Benefits
!width="235"|Restrictions
!width="15"|GLP 
|- align=left
| style="border:1px solid blue;"|'''M-005'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=M-005_Dual_Channel_Parallel_Injection_-_LEAP_Shell_%22(M-Fab)%22]
| style="border:1px solid blue;"|'''Dual Channel Parallel Injection'''<br><br>Provides minimum cycle times by limiting the acquisition time to just the peaks of interest and regenerating columns during acquisition
| style="border:1px solid blue;"|LEAP Shell
| style="border:1px solid blue;"|* DoubleStack valve<br>* 6 port injection valve<br>* FWS in front of 6 port valve<br>* Gradient Pump<br>* Regeneration pump
| style="border:1px solid blue;"|* Integration with Analyst Software<br>* Single Sample List<br> * Provides staggering of injections<br> * Multiplexes 2 separate LC systems into on MS
| style="border:1px solid blue;"|* Does not support 21CFR11 compliance<br>* Requires pumps to be integrated with LEAP Shell
| style="border:1px solid blue;"|No
|}
<br>
{| cellpadding="6" style="border:1px solid darkgray;"
|- align=left
!width="20"|Code
!width="195"|Application
!width="85"|Control SW
!width="140"|Key Hardware
!width="205"|Key Benefits
!width="235"|Restrictions
!width="15"|GLP 
|- align=left
| style="border:1px solid blue;"|'''M-006'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=M-006_%26_M-007_In-Line_Sample_Concentration_or_Filtration]
| style="border:1px solid blue;"|'''Inline Sample Concentration'''<br><br>SPE Column regenerated during analytical extraction
| style="border:1px solid blue;"|Analyst with ICC-CE
| style="border:1px solid blue;"|* TrioVS<br>
| style="border:1px solid blue;"|* Automated concentration and elution of sample on SPE column prior to separation on analytical column
| style="border:1px solid blue;"|* No "Look Ahead" <br>* Can not prep samples ahead of analytical run
| style="border:1px solid blue;"|No
|}
<br>
{| cellpadding="6" style="border:1px solid darkgray;"
|- align=left
!width="20"|Code
!width="195"|Application
!width="85"|Control SW
!width="140"|Key Hardware
!width="205"|Key Benefits
!width="235"|Restrictions
!width="15"|GLP 
|- align=left
| style="border:1px solid blue;"|'''M-007'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=M-006_%26_M-007_In-Line_Sample_Concentration_or_Filtration]
| style="border:1px solid blue;"|'''Inline Sample Filtration'''<br><br>SPE Column regenerated during analytical extraction
| style="border:1px solid blue;"|Analyst with ICC-CE
| style="border:1px solid blue;"|* TrioVS<br>
| style="border:1px solid blue;"|* Automated filtration of sample on cleanup column prior to separation on analytical column
| style="border:1px solid blue;"|* No "Look Ahead" <br>* Can not prep samples ahead of analytical run
| style="border:1px solid blue;"|No
|}
<br>
{| cellpadding="6" style="border:1px solid darkgray;"
|- align=left
!width="20"|Code
!width="195"|Application
!width="85"|Control SW
!width="140"|Key Hardware
!width="205"|Key Benefits
!width="235"|Restrictions
!width="15"|GLP 
|- align=left
| style="border:1px solid blue;"|'''M-008'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=M-008_%26_M-009_Dual_Channel_In-Line_Sample_Concentration_or_Filtration]
| style="border:1px solid blue;"|'''Dual Channel In-line Sample Concentration'''<br><br>SPE Column regenerated during analytical extraction
| style="border:1px solid blue;"|Cycle Composer outside of Analyst
| style="border:1px solid blue;"|* TrioVS<br>
| style="border:1px solid blue;"|* Dual Stream <br>* High throughput sample cleanup "Look Ahead"
| style="border:1px solid blue;"|* Requires two matching sample lists 
| style="border:1px solid blue;"|No
|}
<br>
{| cellpadding="6" style="border:1px solid darkgray;"
|- align=left
!width="20"|Code
!width="195"|Application
!width="85"|Control SW
!width="140"|Key Hardware
!width="205"|Key Benefits
!width="235"|Restrictions
!width="15"|GLP 
|- align=left
| style="border:1px solid blue;"|'''M-009'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=M-008_%26_M-009_Dual_Channel_In-Line_Sample_Concentration_or_Filtration]
| style="border:1px solid blue;"|'''Dual Channel in-line Sample Filtration'''<br><br>SPE Column regenerated during analytical extraction
| style="border:1px solid blue;"|Cycle Composer outside of Analyst
| style="border:1px solid blue;"|* TrioVS<br>
| style="border:1px solid blue;"|* Dual Stream <br>* High throughput sample cleanup <br>* "Look Ahead"
| style="border:1px solid blue;"|* Requires two matching sample lists 
| style="border:1px solid blue;"|No
|}
<br>
{| cellpadding="6" style="border:1px solid darkgray;"
|- align=left
!width="20"|Code
!width="195"|Application
!width="85"|Control SW
!width="140"|Key Hardware
!width="205"|Key Benefits
!width="235"|Restrictions
!width="15"|GLP 
|- align=left
| style="border:1px solid blue;"|'''M-010'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=M-010_%26_M011_Dual_Channel_In-Line_Sample_Concentration_or_Filtration_-_LEAP_Shell]
| style="border:1px solid blue;"|'''Dual Channel in-line Sample Concentration'''<br><br>SPE Column regenerated during analytical extraction
| style="border:1px solid blue;"|LEAP Shell
| style="border:1px solid blue;"|* TrioVS<br>
| style="border:1px solid blue;"|* High throughput sample cleanup "Look Ahead"
| style="border:1px solid blue;"|
| style="border:1px solid blue;"|No
|}
<br>
{| cellpadding="6" style="border:1px solid darkgray;"
|- align=left
!width="20"|Code
!width="195"|Application
!width="85"|Control SW
!width="140"|Key Hardware
!width="205"|Key Benefits
!width="235"|Restrictions
!width="15"|GLP 
|- align=left
| style="border:1px solid blue;"|'''M-011'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=M-010_%26_M011_Dual_Channel_In-Line_Sample_Concentration_or_Filtration_-_LEAP_Shell]
| style="border:1px solid blue;"|'''Dual Channel in-line Sample Filtration'''<br><br>SPE Column regenerated during analytical extraction
| style="border:1px solid blue;"|LEAP Shell
| style="border:1px solid blue;"|* TrioVS<br>
| style="border:1px solid blue;"|* High throughput sample cleanup "Look Ahead"
| style="border:1px solid blue;"|
| style="border:1px solid blue;"|No
|}
<br>
{| cellpadding="6" style="border:1px solid darkgray;"
|- align=left
!width="20"|Code
!width="195"|Application
!width="85"|Control SW
!width="140"|Key Hardware
!width="205"|Key Benefits
!width="235"|Restrictions
!width="15"|GLP 
|- align=left
| style="border:1px solid blue;"|'''M-014'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=Selectable_HPLC_Streams]
| style="border:1px solid blue;"|'''Selectable HPLC'''<br><br>(max 2 Streams)
| style="border:1px solid blue;"|Analyst Standard Cycles
| style="border:1px solid blue;"|* Two Injection Valves<br>* MS Stream Selector 
| style="border:1px solid blue;"|* Different Analyst Methods inject into different LC Valves <br>* Uses Standard Analyst cycles
| style="border:1px solid blue;"|* Requires Analyst control of the stream selector valve <br>* Max of 2 streams can be supported
| style="border:1px solid blue;"|Yes
|}
<br>
{| cellpadding="6" style="border:1px solid darkgray;"
|- align=left
!width="20"|Code
!width="195"|Application
!width="85"|Control SW
!width="140"|Key Hardware
!width="205"|Key Benefits
!width="235"|Restrictions
!width="15"|GLP 
|- align=left
| style="border:1px solid blue;"|'''M-015'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=Selectable_HPLC_Streams]
| style="border:1px solid blue;"|'''Selectable HPLC'''<br><br>(max 4 Streams)
| style="border:1px solid blue;"|Analyst with ICC-CE
| style="border:1px solid blue;"|* Multiple Injection Valves (serial control)<br>* PAL 10 port Valve for Stream Selector 
| style="border:1px solid blue;"|* Different Analyst Methods inject into different LC Valves <br>* Stream selection to MS
| style="border:1px solid blue;"|* PAL controls the stream selector valve <br>* Requires Custom Cycle
| style="border:1px solid blue;"|Yes
|}
<br>
{| cellpadding="6" style="border:1px solid darkgray;"
|- align=left
!width="20"|Code
!width="195"|Application
!width="85"|Control SW
!width="140"|Key Hardware
!width="205"|Key Benefits
!width="235"|Restrictions
!width="15"|GLP 
|- align=left
| style="border:1px solid blue;"|'''M-016'''<br>[http://www.leapwiki.com/mediawiki/index.php?title=Column_Selection]
| style="border:1px solid blue;"|'''Column Selection'''<br><br> Method selects which HPLC column is in-line before injection
| style="border:1px solid blue;"|Analyst with ICC-CE
| style="border:1px solid blue;"|* CTC Column Selector <br>* Up to 5 columns 
| style="border:1px solid blue;"|* Automated switching between analytical columns within run
| style="border:1px solid blue;"|* Requires Custom Cycles
| style="border:1px solid blue;"|Yes
|}
=== For other cost/time saving measures consider:===
* LEAP offers multiple choices of Valve Self Wash Stations to aid in cleaning the valve [http://www.leapwiki.com/mediawiki/index.php?title=Valve_Washing]
* LEAP offers custom sample prep and inject with Analyst and other data systems
* LEAP Shell Software and application for custom injections and scheduling [http://www.leaptec.com/software/leap-shell-3.php]

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''' Print '''
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[[image:Download Icon.png|40px]] [[:Image:Summary_LC_Multi_Valve_Applications.pdf‎ | PDF of Summary LC Multi Valve_Applications page formatted for printing]]
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[[Image:LEAP Logo.png|frame|[http://www.leaptec.com leaptec.com]<br />[http://www.leapwiki.com leapwiki.com]]]

LEAP provides automated workstation instrumentation solutions based on the LEAP CTC PAL X, Y, Z syringe only autosampler robot from LEAP Technologies. This extremely flexible, precise, and adaptable liquid handling robotic platform is available in a variety of lengths and options depending on the requirements of your sample preparation and injections for your UHPLC, LC or GC chromatography.LEAP offers full support and service for the PAL platform in addition to being able to write custom macros, cycles, and scheduling to your applications. Please contact LEAP Technologies on how we can help you get maximized throughput with flexible pipetting automation solutions.

=== Contact LEAP ===

[[image:Contact_Info.png‎|40px]] [http://www.leaptec.com/contact-us.php Contact the LEAP office]


'''Keywords:''' Dual Channel, Single channel, Serial Injection, shorter cycle times, regeneration of columns, Analyst Software, PAL, 10 port, gradient pump, regeneration pump, 6 port injection valve,  saving, back cut, increase throughput, compliance, Look Ahead, staggered injections,  Peaks of interest early, columns, alternating samples, front cut, divert to waste, solvent, TRIOVS, saving of regeneration back cut, parallel injections, cycle composer, staggering of injections, minimum cycle times, acquisition time, Flux pumps, Multiplexes, 2 separate LC systems into one Mass Spec, 21CFR11 compliance, LEAP Shell software, In-line sample concentration, SPE Column regenerated during analytical extraction, prep samples ahead of analytical run, In line sample filtration, In-line concentration, Dual Stream, sample cleanup, column regeneration, concentration,  Analyst Cycles, Stream Selector valve, PAL control, custom cycles, macros, CTC Column selector, Column selection, 4 streams, selectable HPLC, 2 streams, 4 streams, IC-CE software
[[Category:LC Multi Valve Applications]]