Online Sample Cleanup using column switching with Multi-Valve system

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A setup of four valves (1 injection valve and 1 TrioVS 3-valve system) is used to accomplish solid phase sample extraction by one (1) pre-column followed by chromatography on two (2) analytical columns. The goal is an increase in throughput by simultaneously executing sample preparation tasks and one of the two gradient runs. Gradient runs themselves do not occur in a staggered fashion.


Project Ref: H1099

For other cost/time saving measures consider:

  • LEAP offers multiple choices of Valve Self Wash Stations to aid in cleaning the valve [1]
  • Dual Channel Serial Injection with Front Cut (M-002) using Analyst and ICC-CE [2]
  • Dual Channel Parallel Injection (M-003) using Cycle Composer Software and Analyst [3]
  • “Look Ahead”, sample prep before injection (M-004) using LEAP Shell Software [4]
  • Dual Channel Parallel Injection (M-005) using LEAP Shell software [5]
  • Summary of LC Multi Valve Applications [6]
  • LEAP Shell Software and application for custom injections and scheduling [7]

Contact LEAP

For additional information about this technique please contact LEAP Technologies for detailed information



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