Category:DBS

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(New page: {{LSApp |name = DLW (Dynamic Load and Wash) for Fast and Clean LC/MS Loading |image = DLW_Header.png |type = Washing LC Valve |id = DLW (Dynamic Load a...)
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{{LSApp
 
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  |name        = DLW (Dynamic Load and Wash) for Fast and Clean LC/MS Loading
 
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  |image      = DLW_Header.png
 
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  |type        = Washing LC Valve
 
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  |id          = DLW (Dynamic Load and Wash) for Fast and Clean LC/MS Loading
 
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  |description = 
 
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}}
 
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[[Image:DLW1.jpg|900px|center]]
 
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=== DBS (Dried Blood SpotDynamic Load and Wash) for Fast and Clean LC/MS Loading ===
 
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* The '''DLW''',Dynamic Load and Wash,  is designed for today’s most sensitive MS instruments this completely new injection and wash concept gives Near Zero Carryover and can drastically reduced cycle times. The linked combination of the two steps which are usually separate - minimizes cycle time and carry over. The '''DLW''',Dynamic Load and Wash,  is designed to be used on the PAL[http://leapwiki.com/mediawiki/index.php?title=Category:PAL] line of robots.
 
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=== Main Features of DLW ===
 
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* Near Zero Carryover - Typically less than 0.003%
 
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* Reduced wash cycling times- Typical Clean Cycle time less that 1 minute (Fast Cycle)
 
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* Holding loop for effective rinsing of the complete sample path
 
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* Inert sampling path - No contact with syringe, only PEEK tubing and stainless steel
 
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* Reproducible - < 1% RSD
 
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* Minimum sample contact - wetted parts are stainless steel and PEEK
 
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* Integrated pumps for active wash solvent delivery selectable wash time for organic and aqueous solvents
 
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* Two Solvent Wash - Complete cleaning from the opposite direction of sampling
 
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* Spring loaded syringe needle positioning in needle guide – no dead volume
 
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* Flexible - HPLC and UHPLC applications
 
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* Robust - Spring loaded syringe needle positioning
 
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* Can be run from Analyst 1.5 as standard cycles without additional software
 
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* Upgradable - Existing PAL systems can be upgraded
 
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<br>
 
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'''The features include:'''
 
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* A new state-of-the-art new electronics board
 
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* Dynamic Load and Wash (DLW) concept
 
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* Clean and efficient removal of carryover in the entire flow path
 
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<br>
 
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'''This results in:'''
 
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* Keeping sample away from the syringe, plus fast, effective washing of all wetted path
 
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* Near-zero carryover results from run to run
 
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* Larger memory capacity for more objects
 
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* Faster basic motor speeds
 
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* Controls additional solenoid valves and other accessories
 
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* Externally exchangeable fuse, which protects electronics
 
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* Ethernet as well as RS 232 interface
 
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* New firmware 4.x not available for old boards
 
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CTC Analytics, the manufacturer of the PAL sampling and high throughput systems, has announced the release of the '''Dynamic Load and Wash''' (DLW). This upgrade has undergone rigorous customer testing and has proven to be extremely effective in removing carryover. With DLW option, the sample is no longer in contact with the syringe but it is aspirated into a holding loop located in front of the syringe. The syringe acts only as an aspirating and dispensing device and provides the excellent reproducibility seen in standard syringe injection systems. After the injection on tho the valve the whole sample path including the valve and the needle is washed with up to 2 different solvents. Micro pumps quickly and effectively deliver the required quantity of solvent. All parts which have been in contact with the sample are completely clean. As a result, near-zero carryover is achieved. The DLW is offered in an upgrade kit from LEAP as well as included with all new '''HTC-xt''' and '''HTS-xt''' PALs.
 
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[[Image:Wash_Cycle_Times.png|500px|center]]
 
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[[Image:DLW_Kit.png|500px|center]]
 
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[[Image:Upgrade_kit_for_DLW.png|500px|center]]
 
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<br>
 
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[[image: Info icon.png|40px]] [http://leapwiki.com/mediawiki/index.php?title=Category:HTC-xt LEAP is proud to introduce the newest PAL's the HTC-xt]
 
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<br>
 
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[[image: Info icon.png|40px]] [http://leapwiki.com/mediawiki/index.php?title=Category:HTS-xt LEAP is proud to introduce the newest PAL's the HTS-xt]
 
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<br>
 
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=== Who may benefit:===
 
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* High throughput users- Fast wash cycles
 
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* High Sensitivity Detection users
 
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* Existing users of PAL  – xt Upgrade Kit is available from LEAP
 
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* New users – Looking for a Faster Cleaner Autosampler
 
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<br>
 
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[[image:Download Icon.png|40px]]  [[:Media:LEAP_-__Fast_Dynamic_Load__Wash.pdf | Animation of Fast Cycle for DLW for PAL]]
 
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<br><br><br>
 
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[[Image:DLW_Data.png|900px|center]]
 
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=== PRINT Brochure ===
 
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<br>
 
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[[image:Download Icon.png|40px]] [[:Media:DLW_for_CTC_PAL_Brochure.pdf | PDF Brochure of DLW for CTC PAL]]<br>
 
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[[image:Download Icon.png|40px]] [[:Media:DLW_poster_Final.pdf‎  | PDF of DLW Comparison of Cycles]]<br>
 
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[[image:Download Icon.png|40px]] [[:Media:DLW_Data_poster_Final.pdf  | PDF of DLW Data]]<br>
 
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=== Videos ===
 
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[[Image:Movie Icon.png|40px]] [http://www.youtube.com/user/LEAPTechnologies#p/a/u/2/LHVFbekdu70 Video Presentation of DLW Webinar Part 1 of 3]
 
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[[Image:Movie Icon.png|40px]] [http://www.youtube.com/user/LEAPTechnologies#p/a/u/1/XZRt__e2RCA Video Presentation of DLW Webinar Part 2 of 3 ]
 
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<br>
 
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[[Image:Movie Icon.png|40px]] [http://www.youtube.com/user/LEAPTechnologies#p/a/u/0/2IauconvItQ Video Presentation of DLW Webinar Part 3 of 3 ]
 
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[[Image:Movie Icon.png|40px]]
 
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[[image:As Seen.PNG |100px|left|As Seen at LEAP]]<br><br><br>
[[image:As Seen.PNG |100px|left|As Seen at LEAP]]<br><br><br>
[[image:CPSA.png |100px|left|DBS Automated PAL]]
[[image:CPSA.png |100px|left|DBS Automated PAL]]

Revision as of 22:27, 11 October 2010

As Seen at LEAP



DBS Automated PAL

As Seen at the CPSA October 2010




LEAP Technologies will present "Novel Walk Away Automation for DBS sample extraction from 4-Spot Cards to LC-MS" at the CPSA 2010 annual meeting being held at the Bucks County Sheraton Hotel, 400 Oxford Valley Road, Langhorne, Pennsylvania 19047.
To see information about this Dried Blood Spot system please visit us on Tuesday, October 19th from 1 - 3:30pm at our Poster.

The Dry Blood Spot (DBS) technique of eluding the blood sample from filter paper cards still lacks simple, reliable and inexpensive automation. There are approx.100 methods/applications known for these sample carrier DBS cards. In many such areas automation would be a tremendous benefit. It would not only be labor saving, but also decrease handling, which means less errors and more consistency in getting the samples introduced into a separation and then the analytical system.
The poster goes through the work flow of the automation approach step by step. The experience with hardware and software so far will be reviewed, including experience with the built-in internal standard addition. The SCAP DBS has patent pending technology applied and is simple to use. The approach of eluting the dry blood sample off the card directly to a multi-column system by-passes all manual and cumbersome treatment steps of the sample cards. First results from needed cycle times and throughput will be presented. Beta test results with analytical data compared to the traditional manual method will also be shown


 ↳ leaptec.com  ↳ leapwiki.com
 ↳ leaptec.com
 ↳ leapwiki.com

LEAP strives to find total solutions for analytical lab automation by automating analytical processes for small and large molecules in extracted liquids, solids, and recently in human, animal and plant tissues. We provide the precise robotics and efficient sample prep required by modern measurement techniques such as MALDITOF mass spectroscopy. Our newest specialty customization of CTC Analytics’ PAL features small workstations that can perform complex liquid handling tasks including HPLC-Purification, SPE, filtration, weighing, heating and stirring. They can be configured as stand alone units or integrated for “just in time” sample prep for LC-MS or GC-MS analysis.
LEAP provides automated workstation instrumentation solutions based on the LEAP CTC PAL X, Y, Z syringe only autosampler robot from LEAP Technologies. This extremely flexible, precise, and adaptable liquid handling robotic platform is available in a variety of lengths and options depending on the requirements of your sample preparation and injections for your UHPLC, LC or GC chromatography.LEAP offers full support and service for the PAL platform in addition to being able to write custom macros, cycles, and scheduling to your applications. Please contact LEAP Technologies on how we can help you get maximized throughput with flexible pipetting automation solutions.

Contact LEAP

Contact LEAP

For additional information about LEAP and the PAL Platform, please contact LEAP Technologies.

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