Category:DBS
From LEAP
As Seen at the CPSA October 2010
LEAP Technologies will present "Novel Walk Away Automation for DBS sample extraction from 4-Spot Cards to LC-MS" at the CPSA 2010 annual meeting being held at the Bucks County Sheraton Hotel, 400 Oxford Valley Road, Langhorne, Pennsylvania 19047.
To see information about this Dried Blood Spot system please visit us on Tuesday, October 19th from 1 - 3:30pm at our Poster.
The Dry Blood Spot (DBS) technique of eluding the blood sample from filter paper cards still lacks simple, reliable and inexpensive automation until today with LEAP Technologies and the PAL Platform. There are approx.100 methods/applications known for these sample carrier DBS cards. In many such areas automation will be a tremendous benefit. It will not only be labor saving, but also decrease handling, which means less errors and more consistency in getting the samples introduced into a separation and then the analytical system.
The poster goes through the work flow of the automation approach step by step. The experience with hardware and software so far will be reviewed, including experience with the built-in internal standard addition. The SCAP DBS has patent pending technology applied and is simple to use. The approach of eluting the dry blood sample off the card directly to a multi-column system by-passes all manual and cumbersome treatment steps of the sample cards. First results from needed cycle times and throughput will be presented. Beta test results with analytical data compared to the traditional manual method will also be shown. We look forward to sharing this exciting new technique with you.
LEAP strives to find total solutions for analytical lab automation by automating analytical processes for small and large molecules in extracted liquids, solids, and recently in human, animal and plant tissues. We provide the precise robotics and efficient sample prep required by modern measurement techniques such as MALDITOF mass spectroscopy. Our newest specialty customization of CTC Analytics’ PAL features small workstations that can perform complex liquid handling tasks including HPLC-Purification, SPE, filtration, weighing, heating and stirring. They can be configured as stand alone units or integrated for “just in time” sample prep for LC-MS or GC-MS analysis.
LEAP provides automated workstation instrumentation solutions based on the LEAP CTC PAL X, Y, Z syringe only autosampler robot from LEAP Technologies. This extremely flexible, precise, and adaptable liquid handling robotic platform is available in a variety of lengths and options depending on the requirements of your sample preparation and injections for your UHPLC, LC or GC chromatography.LEAP offers full support and service for the PAL platform in addition to being able to write custom macros, cycles, and scheduling to your applications. Please contact LEAP Technologies on how we can help you get maximized throughput with flexible pipetting automation solutions.
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For additional information about LEAP and the PAL Platform, please contact LEAP Technologies. |
Keywords: SCAP, Dried Blood Spot,DBS, online extraction, automated sample extraction platform for online LC-MS/MS bioanalysis, sample card, automated, placement, DBS integrated sample processing, superior alternative, fully automated, optimized extraction of DBS, simplified method development by online extraction, fully automated process saves time and labor costs, no need for additional consumables or centrifuge / filtration, PAL, multiple clamp adapters, LEAP, CTC, HTS, HTS, HTX, Drug metabolism (DM), pharmacokinetic (PK) and toxicokinetic (TK) studies, DMPK, process DBS samples rapidly and with great precision using robotic systems specially developed for the purpose, practical solution to processing after with shipping and storing blood samples that require controlled handling and frozen transportation and storage, systems that can prepare and process large quantities of Dried Blood Spot (DBS) samples for LC/MS/MS analysis, Dried Blood Spots Replacing Plasma Samples,new flow through concept that allows for the direct analysis of sample spots from paper into the mass spectrometer via online solid-phase extraction, The dried blood spot (DBS) method is an alternative technique that overcomes traditional drawbacks like (manual punching and extracting, Dried blood spots (DBS) have been used for years for HIV-1 RNA, DNA, Genotyping, and other diagnostic assays, increase in sensitivity is obtained using this direct flow through elution technique, compared to the punch and elute method, Dried blood spots can be used as an easy and inexpensive means for the collection and storage of peripheral blood specimens from infants, children and adults in settings where collection and storage of plasma is not optimal. Dried blood spots use a small amount of peripheral blood on protein saver filter paper cards from infant heel pricks, or finger sticks from adults and require less skill and supplies than venous blood draws, automation after elution of the sample off a dry card format with an autosampler, the cost and difficulties of cold chain shipping of plasma samples is greatly reduced by the use of dried blood spots and they can be shipped as non-dangerous goods.Widely used to screen for metabolic problems in newborn babies, it is now being successfully employed in PK studies,The use of dried blood spot (DBS) to acquire, ship, store, and test samples is not new. However, it has gained tremendous visibility and is rapidly being adopted in all aspects of bioanalysis. In the near term, it is actually more challenging for bioanalytical scientists. The development of automation for the DBS format and newer technology similar to dried blood spotting will be developed to overcome that challenge, manual punching and extracting,Direct elution from card into further solid phase extraction clean-up,Whatman DMPK cards,Flow through DBS extraction device, 4 spot, Dried blood spots (DBS) have been show to be a useful means of collecting, storing and shipping blood samples for quantitative drug analysis and provides many advantages over conventional plasma collection.
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